2011 Fiscal Year Final Research Report
Identification of the therapeutic effect of new enzyme-targeting radiosensitization treatment, KORTUC for tumor stem cells
Project/Area Number |
21591610
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kochi University |
Principal Investigator |
OGAWA Yasuhiro 高知大学, 教育研究部・医療学系, 教授 (90152397)
|
Co-Investigator(Renkei-kenkyūsha) |
NISHIOKA Akihito 高知大学, 教育研究部・医療学系, 准教授 (70237668)
KARIYA Shinji 高知大学, 教育研究部・医療学系, 助教 (20314990)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 放射線腫瘍学 / 乳癌 / 過酸化水素 / 腫瘍幹細胞 / ヒアルロン酸 / 放射線増感剤 |
Research Abstract |
Using PET-CT and MRI, the therapeutic effects of new enzyme-targeting radiosensitization treatment, KORTUC were evaluated following the treatment for breast cancer patients treated by KORTUC without any surgical procedure. CD44-positive breast cancer cells thought to be breast cancer stem cells were detected by an immunohistochemical method using biopsy specimens obtained prior to the treatment. As a results, it was concluded that KORTUC exerted fully therapeutic effect irrespective of the existence of CD44-positive tumor cells.
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[Journal Article] Safety and effectiveness of a new enzyme-targeting radiosensitization treatment(KORTUC II) for intratumoral injection for low-LET radioresistant tumors2011
Author(s)
Ogawa Y, Kubota K, Ue H, Tadokoro M, Matsui R, Yamanishi T, Hamada N, Kariya S, Nishioka A, Nakajima H, Tarutani M, Sano S
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Journal Title
Int J Oncol
Volume: 39
Pages: 553-560
Peer Reviewed
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[Journal Article] Evaluation of changes in tunor shadows and microcalcifications on mammography following KORTUC II, a new radiosensitization treatment without any surgical procedure for elderly patients with stage I and II breast cancer2011
Author(s)
Tsuzuki A, Ogawa Y, Kubota K, Tokuhiro S, Akima R, Yaogawa S, Itoh zk, Yamada Y, Sasaki T, Onogawa M, Yamanishi T, Kariya S, Nogami M, Nishioka A, Miyamura M
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Journal Title
Cancers
Volume: 3
Pages: 3496-3505
Peer Reviewed
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[Presentation] KORTUC II. A new image-guided, enzyme-targeted, and breast cancer stem cell targeted radiosensitization treatment for patients with stage I and II breast cancers2011
Author(s)
Ogawa Y, Kubota K, Tadokoro M, Yamanishi T, Aoyama N, Suzuki Y, Iwasa H, Kariya S, Nogami M, Nishioka A
Organizer
53^<rd> Annual Meeting of the American Society for Radiation Oncology
Place of Presentation
Miami Beach, USA
Year and Date
2011-10-03
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[Presentation] Evaluation of changes of tumor shadows and micro-calcifications on mammography following a new radiosensitization treatment(KORTUC II) for aged patients with breast cancer of stages I and II2010
Author(s)
Tsuzuki A, Ogawa Y, Kubota K, Nishioka A, Akima R, Tokuhiro S, Yaogawa S, Yamada Y, Sasaki T, Geshi H
Organizer
52nd Annual Meeting of the American Society for Radiation Oncology
Place of Presentation
San Diego, USA
Year and Date
2010-11-02
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