2011 Fiscal Year Final Research Report
Endovascular treatment of experimental aneurysms in swine model by use of mesenchymal stem cells-coated stents.
| Project/Area Number |
21591852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOUKIN Kiyohiro 札幌医科大学, 医学部, 教授 (90229146)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 移植再生医療 / 脳血管内治療 / 再生医学 / 神経科学 / 発生分化 |
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| Research Abstract |
The purpose of this study was to determine whether implanting exogenous mesenchymal stem cells on stents could enhance aneurysmal neck healing. I thought hypotheses included that mesenchymal stem cells-coated stents can improve angiographic and histopathologic results after endovascular treatment. Mesenchymal stem cells-coated stents were not effective for accelerating organization of the aneurysms cavity and developing neointima after endovascular treatment. This is a promising novel procedure to repair aneurysm , and may provide a new way to induce plasticity in mesenchymal stem cells.
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