2011 Fiscal Year Final Research Report
Development of new neuro-protective and normo-thrermic hibernation therapy using intra-cisternal infusion of magnesium sulfate solution
| Project/Area Number |
21591857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Juntendo University |
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Principal Investigator |
MORI Kentaro 順天堂大学, 医学部, 教授 (30200364)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Takuji 順天堂大学, 医学部, 先任准教授 (50255684)
NAKAO Yasuaki 順天堂大学, 医学部, 准教授 (50271276)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マグネシウム / 脳保護法 / 遅延性脳神経細胞死 / 海馬 / 脳循環代謝 |
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| Research Abstract |
During mammalian hibernation, magnesium ion(Mg^<2+>) concentration in the brain increases. Based on this fact, we developed the new neuro-protective therapy using cisternal or intra-cerebral magnesium sulfate solution infusion. We demonstrated this therapy suppressed the delayed neuronal death in the hippocampal neurons after the global ischemia. We also showed this neuro-protective effect was not mediated by the suppression of the cerebral blood flow and metabolism.
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