The change of regional cerebral blood flow during the epileptic discharge on epileptic rat models

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: KISHIMA Haruhiko 大阪大学, 医学系・研究科, 講師 (10332743)
• Co-Investigator(Kenkyū-buntansha): SAITOH Yoichi 大阪大学, 産学連携本部, 特任教授(常勤) (20252661) ; SHIMOSEGAWA Eku 大阪大学, 大学院・医学系研究科, 准教授 (30370258)
• Co-Investigator(Renkei-kenkyūsha): OSHINO Satoru 大阪大学, 大学院・医学系研究科, 助教 (40403050) ; MARUO Tomoyuki 大阪大学, 大学院・医学系研究科, 医員 (90533810) ; HOSOMI Koichi 大阪大学, 産学連携本部, 特任助教 (70533800)
• Project Period (FY): 2009 – 2011
• Keywords: てんかん / てんかん発作伝播 / 外科治療 / レーザースペックル血流計

Research Abstract

In this study, the changes of cerebral blood flow(CBF) were analyzed during the epileptic seizure using the rat models. The increase of CBF was observed with some partial seizures. Just before the secondary generalized seizure, once CBF decreased and it increased with the epileptic EEG. It demonstrates that depolarization wave might occurs before generalized seizure.

Research Products

• [Journal Article] Ictal high-frequency oscillations on scalp EEG recordings in symptomatic West syndrome (2012)
  • Author(s): Iwatani Y, K Kagitani-Shimono, K Tominaga, T Okinaga, H Kishima, A Kato, T Nagai, K Ozono
  • Journal Title: Epilepsy Res. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Long-term developmental outcome in patients with West syndrome after epilepsy surgery (2012)
  • Author(s): Iwatani Y, Kagitani-Shimono K, Tominaga K, Okinaga T, Mohri I, Kishima H, Kato A, Sanefuji W, Yamamoto T, Tatsumi A, Murata E, Taniike M, Nagai T, Ozono K
  • Journal Title: Brain Dev Volume: (In press)
  • Peer Reviewed
• [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients (2012)
  • Author(s): Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
  • Journal Title: Ann Neurol Volume: 71(3) Pages: 353-61
  • Peer Reviewed
• [Journal Article] Real-time control of a prosthetic hand using human electrocorticography signals (2011)
  • Author(s): Yanagisawa T, Hirata M, Saitoh Y, Goto T, Kishima H, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
  • Journal Title: J Neurosurg Volume: 114(6) Pages: 1715-22
  • Peer Reviewed
• [Journal Article] Deep brain stimulation of the subthalamic nucleus improves temperature sensation in patients with Parkinson' s disease (2011)
  • Author(s): Maruo T, Saitoh Y, Hosomi K, Kishima H, Shimokawa T, Hirata M, Goto T, Morris S, Harada Y, Yanagisawa T, Aly MM, Yoshimine T
  • Journal Title: Pain Volume: 152(4) Pages: 860-5
  • Peer Reviewed
• [Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation(STS) prosthesis in dogs (2011)
  • Author(s): Morimoto T, Kamei M, Nishida K, Sakaguchi H, Kanda H, Ikuno Y, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K, Fujikado T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(9) Pages: 6785-92
  • Peer Reviewed
• [Journal Article] Quantitative analysis of phosphenes induced by navigation-guided repetitive transcranial magnetic stimulation (2011)
  • Author(s): Tani N, Hirata M, Motoki Y, Saitoh Y, Yanagisawa T, Goto T, Hosomi K, Kozu A, Kishima H, Yorifuji S, Yoshimine T
  • Journal Title: Brain Stimul Volume: 4(1) Pages: 28-37
  • Peer Reviewed
• [Journal Article] Frequency-dependent spatiotemporal distribution of cerebral oscillatory changes during silent reading : a magnetoencephalograhic group analysis (2011)
  • Author(s): Goto T, Hirata M, Umekawa Y, Yanagisawa T, Shayne M, Saitoh Y, Kishima H, Yorifuji S, Yoshimine T
  • Journal Title: Neuroimage Volume: 54(1) Pages: 560-7
  • Peer Reviewed
• [Journal Article] Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa (2011)
  • Author(s): Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Ikuno Y, Nishida K, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(7) Pages: 4726-33
  • Peer Reviewed
• [Journal Article] Modulation of neuronal activity after spinal cord stimulation for neuropathic pain ; H(2) 15O PET study (2010)
  • Author(s): Kishima H, Saitoh Y, Oshino S, Hosomi K, Ali M, Maruo T, Hirata M, Goto T, Yanagisawa T, Sumitani M, Osaki Y, Hatazawa J, Yoshimine T
  • Journal Title: Neuroimage Volume: 49(3) Pages: 2564-9
  • Peer Reviewed
• [Presentation] Posterior Quadrantectomyの位置づけとその適応 (2012)
  • Author(s): 貴島晴彦、押野悟、平田雅之、谷直樹、細見晃一、圓尾知之、後藤哲、クウウイミン、齋藤洋一、加藤天美、吉峰俊樹
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] フレームレスイメージガイド定位手術を用いた深部電極留置術 (2012)
  • Author(s): クウウイミン、貴島晴彦、押野悟、谷直樹、細見晃一、圓尾知之、後藤哲、平田雅之、齋藤洋一、吉峰俊樹
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] てんかん焦点における糖代謝と中枢性ベンゾジアゼピン受容体分布のミスマッチ (2012)
  • Author(s): 細見晃一、貴島晴彦、押野悟、木下学、平田雅之、谷直樹、後藤哲、圓尾知之、KhooHuiMing, 齋藤洋一、吉峰俊樹
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] てんかんモデルに対するレーザースペックル血流計を用いた脳血流イメージ解析 (2012)
  • Author(s): 圓尾知之、貴島晴彦、中村元、押野悟、谷直樹、細見晃一、クウウイミン、齋藤洋一、吉峰俊樹
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] 新皮質てんかんに対する外科治療の長期予後予測因子の検討 (2011)
  • Author(s): 貴島晴彦、押野悟、細見晃一、平田雅之、谷直樹、圓尾知之、Khoo Hui Ming、柳澤琢史、下野九理子、沖永剛志、齋藤洋一、加藤天美、吉峰俊樹
  • Organizer: 日本脳神経外科学会第70回学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-12
• [Presentation] 新皮質てんかんに対する外科治療の予後予測因子の検討 (2011)
  • Author(s): 貴島晴彦、押野悟、細見晃一、平田雅之、圓尾知之、谷直樹、クーウイミン、柳澤琢史、下野九理子、沖永剛志、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-07
• [Presentation] 高齢者の非痙攣性てんかん重積に対する治療経験 (2011)
  • Author(s): 押野悟、竹綱成典、松本勝美、鶴薗浩一郎、貴島晴彦、吉峰俊樹
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] 内側側頭葉てんかんにおける中枢性ベンゾジアゼピン受容体と糖代謝分布の相違 (2011)
  • Author(s): 細見晃一、貴島晴彦、押野悟、木下学、平田雅之、後藤哲、圓尾知之、Hui Minig Khoo、下野九理子、沖永剛志、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] 海馬電極刺激を用いた海馬扁桃核切除後の記憶障害の予測 (2011)
  • Author(s): 谷直樹、貴島晴彦、アリモハメド、押野悟、細見晃一、クーウイミン、圓尾知之、平田雅之、齋藤洋一、加藤天美、数井裕光、吉田哲彦、吉峰俊樹
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] フレームレス定位手術システムを用いて深部電極を留置した側頭葉てんかんの1例 (2011)
  • Author(s): クーウイミン、貴島晴彦、押野悟、谷直樹、細見晃一、圓尾知之、後藤哲、平田雅之、齋藤洋一、吉峰俊樹
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] Provocative memory test for amygdalohippocampectomy using depth electrodes implanted in the entorhinal area (2011)
  • Author(s): Tani N, Kishima H, Ali M, Oshino S, Hosomi K, Kui Ming K, Maruo T, Saitoh Y, Hirata M, Kato A, Kazui H, Yoshida T, Yoshimine T
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Poster, Italy
  • Year and Date: 2011-08-31
• [Presentation] Navigation guided less invasive selective amigrdalohippocampectomy via inferior temporal gyrus (2011)
  • Author(s): Kishima H, Oshino S, Hirata M, Tani N, Hosomi K, Maruo T, Saitoh Y, Kato A, Yoshimine T
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Poster, Italy
  • Year and Date: 2011-08-31
• [Presentation] How do new anti-epileptic drugs impact the therapy of refractory epilepsy at the municipal hospital in Sakai (2011)
  • Author(s): Ninomiya H, Kato A, Kishima H, Yoshimine T
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Poster, Italy
  • Year and Date: 2011-08-30
• [Presentation] Is Additional Amygdalohippocampectomy Necessary for Intractable Lesional Temporal Lobe Epilepsy (2010)
  • Author(s): Kishima H, Oshino S, Hosomi K, Hirata M, Kato A
  • Organizer: 2010 AMERICAN EPILEPSY SOCIETY
  • Place of Presentation: San Antonio, USA
  • Year and Date: 20101203-07
• [Presentation] 皮質下脳波計測による神経白質線維の活動計測 (2010)
  • Author(s): 後藤哲、平田雅之、橋本直哉、貴島晴彦、柳澤琢史、齋藤洋一、依藤史郎、吉峰俊樹
  • Organizer: 日本脳神経外科学会第69回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 20101027-29
• [Presentation] てんかん外科治療の医学的転帰と社会生活 (2010)
  • Author(s): 貴島晴彦、平田雅之、押野悟、細見晃一、圓尾知之、Mohamed Ali、後藤哲、柳澤琢史、下野九理子、沖永剛志、齋藤洋一、加藤天美、吉峰俊樹
  • Organizer: 日本脳神経外科学会第69回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 20101027-29
• [Presentation] 新規抗てんかん薬でてんかん治療はかわったか (2010)
  • Author(s): 二宮宏智、加藤天美、中野直樹、貴島晴彦、吉峰俊樹
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 20101014-15
• [Presentation] 側頭葉てんかんにおけるIomazenil SPECTとFDG PETの定量的比較 (2010)
  • Author(s): 細見晃一、貴島晴彦、押野悟、平田雅之、Mohamed Ali、後藤哲、原田悠、圓尾知之、Shayne Morris、柳澤琢史、下野九理子、沖永剛志、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 20101014-15
• [Presentation] てんかん手術後の社会的予後の検討 (2010)
  • Author(s): 貴島晴彦、平田雅之、押野悟、細見晃一、圓尾知之、Mohamed Ali、下野九理子、沖永剛志、齋藤洋一、加藤天美、吉峰俊樹
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 20101014-15
• [Presentation] 海馬傍回に留置した深部電極の刺激による記憶機能の評価 (2010)
  • Author(s): Mohamed Ali、貴島晴彦、平田雅之、押野悟、細見晃一、吉田哲彦、数井裕光、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 20101014-15
• [Presentation] Is the Additional Amygdalohippocampectomy Necessary for the Intractable Lesional Temporal Lobe Epilepsy (2010)
  • Author(s): Kishima H, Oshino S, Hosomi K, Hirata M, Yanagisawa T, Goto T, Mohamed A, Shimono K, Okinaga T, Saitoh Y, Kato A
  • Organizer: The 4rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20100903-05
• [Presentation] Quantitative analysis of 123I-iomazenil SPECT in temporal lobe epilepsy (2010)
  • Author(s): Hosomi K, Kishima H, Oshino S, Hirata M, Mohammed A, Goto T, Maruo T, Yanagisawa T, Harada Y, Morris S, Kato A, Saitoh Y, Yoshimine T
  • Organizer: The 4rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20100903-05
• [Presentation] 痙性対麻痺に治するバクロフェン髄腔内投与療法 (2010)
  • Author(s): 貴島晴彦、押野悟、細見晃一、圓尾知之、平田雅之、アリモハメッド、柳澤琢史、後藤哲、齋藤洋一、吉峰俊樹
  • Organizer: 第49回日本定位・機能神経外科学会
  • Place of Presentation: 大阪
  • Year and Date: 20100122-23
• [Presentation] 神経疾患に対する非侵襲的中枢神経刺激療法-反復経頭蓋磁気刺激- (2010)
  • Author(s): 細見晃一、齋藤洋一、貴島晴彦、平田雅之、押野悟、谷直樹、後藤哲、圓尾知之、柳澤琢史、Mohamed Ali、吉峰俊樹
  • Organizer: 第49回日本定位・機能神経外科学会
  • Place of Presentation: 大阪
  • Year and Date: 20100122-23
• [Presentation] 器質性病変を有する側頭葉てんかんに対する病変切除、海馬温存手術の長期予後 (2010)
  • Author(s): 貴島晴彦、押野悟、細見晃一、平田雅之、後藤哲、圓尾知之、柳澤琢史、Mohamed Ali、下野九理子、沖永剛志、齋藤洋一、加藤天美、吉峰俊樹
  • Organizer: 第33回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 20100121-22
• [Presentation] 側頭葉てんかんにおける側頭葉外の抑制系障害-Iomazenil-SPECTを用いて (2010)
  • Author(s): 細見晃一、貴島晴彦、押野悟、平田雅之、後藤哲、圓尾知之、柳澤琢史、Mohamed Ali、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第33回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 20100121-22
• [Presentation] 広汎性発達障害を伴う全般性てんかんに対して脳梁離断術を施行した2例 (2010)
  • Author(s): 貴島晴彦、押野悟、平田雅之、細見晃一、後藤哲、圓尾知之、齋藤洋一、吉峰俊樹、富永康二、下野九理子、沖永剛志
  • Organizer: 第6回日本てんかん学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-24
• [Presentation] 二次性全般化に認められた高アンモニア血症の2例 (2009)
  • Author(s): 二宮宏智、貴島晴彦、加藤天美、吉峰俊樹
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前(青森)
  • Year and Date: 20091022-24
• [Presentation] 側頭葉てんかんにおける123I-iomazenil SPECTの定量解析の試み (2009)
  • Author(s): 細見晃一、貴島晴彦、押野悟、平田雅之、後藤哲、圓尾知之、柳澤琢史、Mohamed Ali、下野九理子、沖永剛志、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前(青森)
  • Year and Date: 20091022-24
• [Presentation] 前方脳梁離断術後の発作間欠期脳磁図の変化 (2009)
  • Author(s): 押野悟、貴島晴彦、平田雅之、細見晃一、後藤哲、柳澤琢史、Mohamed Ali、圓尾知之、齋藤洋一、下野九理子、沖永剛志、加藤天美、吉峰俊樹
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前(青森)
  • Year and Date: 20091022-24
• [Presentation] 器質性病変を有する側頭葉てんかんに対する外科治療法 (2009)
  • Author(s): 貴島晴彦、押野悟、細見晃一、平田雅之、柳澤琢史、後藤哲、Mohamed Ali、下野九理子、沖永剛志、加藤天美、齋藤洋一、吉峰俊樹
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前(青森
  • Year and Date: 20091022-24
• [Presentation] 感覚運動野の新皮質てんかんにおける発作間欠期てんかん波の自発的運動による抑制効果 (2009)
  • Author(s): 柳澤琢史、平田雅之、貴島晴彦、後藤哲、齋藤洋一、押野悟、細見晃一、加藤天美、吉峰俊樹
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 弘前(青森)
  • Year and Date: 20091022-24
• [Presentation] Functional hemispherotomy by vertical method using neuronavigation (2009)
  • Author(s): Kato A, Kishima H, Nakano N, Lin S, Shimono K, Okinaga T, Tsuyuguchi N, Oshino S, Ninomiya H, Hirata M, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Occupational achievement after surgery for temporal lobe epilepsy (2009)
  • Author(s): Kishima H, Oshino S, Hirata M, Hosomi K, Yanagisawa T, Goto T, Maruo T, Mohammed A, Kato A, Sitoh Y, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Language dominance and mapping based on neuromagnetic oscillatory change : comparison with invasive procedures (2009)
  • Author(s): Hirata M, Goto T, Barnes G, Kishima H, Oshino S, Yanagisawa T, Saitoh Y, Kato A, Hshimoto N, Yorifuji S, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Quantitative analysis of 123I-iomazenil SPECT in temporal lobe epilepsy (2009)
  • Author(s): Hosomi K, Kishima H, Oshino S, Hirata M, Goto T, Maruo T, Yanagisawa T, Mohammed A, Kato A, Saitoh Y, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Alteration of interictal epileptic discharge after anterior corpus callosotomy (2009)
  • Author(s): Oshino S, Kishima H, Hirata M, Hosomi K, Goto T, Yanagisawa T, Mohamed A, Maruo T, Saitoh Y, Kato A, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Identification of epiliptogenic focus in patients with tuberous sclerosis complex using MEG ; Report of two cases (2009)
  • Author(s): Mohamed A, Kishima H, Hosomi K, Oshino S, Hirata M, Yanagisawa T, Maruo T, Goto T, Saitoh Y, Kato A, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Presentation] Movement induces suppression of interictal spikes in sensorimotor neocortical epilepsy (2009)
  • Author(s): Yanagisawa T, Hirata M, Kishima H, Goto T, Saitoh Y, Oshino S, Hosomi K, Kato A, Yoshimine T
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20090618-19
• [Book] インタビュー最前線の医師たち,てんかん治療の現在(長期的視点が必要となるてんかん治療)ライフ・サイエンスMedicament News第2079号 (2012)
  • Author(s): 貴島晴彦
  • Total Pages: 17
  • Publisher: ライフ・サイエンス
• [Book] 3.頭部外傷,日本てんかん協会,てんかんと基礎疾患てんかんを合併しやすい、いろいろな病気 (2011)
  • Author(s): 永井利三郎、貴島晴彦
  • Total Pages: 12-14
• [Book] 14.脳腫瘍,日本てんかん協会,てんかんと基礎疾患てんかんを合併しやすい、いろいろな病気 (2011)
  • Author(s): 貴島晴彦
  • Total Pages: 56-62
• [Book] 機能外科,植え込み機器をめぐって, Neurosurgery NOW No.13整容脳神経外科Updateきれいなキズアトを目指して (2011)
  • Author(s): 貴島晴彦
  • Total Pages: 94-100
  • Publisher: メジカルビュー社