2011 Fiscal Year Final Research Report
Contribution of acid-sensing nociceptor molecules (ASIC and TRPV1) to symptom onset in interstitial cystitis
| Project/Area Number |
21592068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shiga University of Medical Science (2010-2011)
University of Yamanashi (2009) |
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Principal Investigator |
ARAKI Isao 滋賀医科大学, 医学部, 准教授 (50252424)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Masayuki 山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
KOBAYASHI Hideki 山梨大学, 医学部付属病院, 助教 (50402053)
YOSHIYAMA Mitsuharu 山梨大学, 医学部, 非常勤講師 (20422694)
MOCHIZUKI Tsutomu 山梨大学, 医学部付属病院, 助教 (50377496)
TSURU Teruhiko 滋賀医科大学, 医学部, 助教 (90625675)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膀胱上皮 / イオンチャネル / 知覚 / 痛み / 炎症 |
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| Research Abstract |
The study elucidated the localization of acid-sensing ion channels (ASICs) in the bladder. The sex-related differences in expression profile of ASIC and in bladder response to intravesical acid irritation indicated that ASICs may contribute to the symptom onset in interstitial cystitis preferably occurring in women by controlling acid sensitivity in the bladder sensory pathway.
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[Journal Article] Decreased expression of the epithelial Ca2+ channel TRPV5 and TRPV6 in human renal cell carcinoma ssociated with vitamin D receptor2011
Author(s)
Wu Y, Miyamoto T, Li K, Nakagomi H, Sawada N, Kira S, Kobayashi H, Zakohji H, Tsuchida T, Fukazawa M, raki I, Takeda M
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Journal Title
J Urol
Volume: 186(6)
Pages: 2419-2425
DOI
Peer Reviewed
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[Journal Article] The Japanese Naftopidil Neurogenic Lower Urinary Tract Dysfunction Study Group: Predictive factors for the effect of alpha1-D/A adrenoceptor antagonist, naftopidil, on subjective and objective parameters in patients with neurogenic lower urinary tract dysfunction2011
Author(s)
Takeda M, Homma Y, Araki I, Kakizaki H, Yamani shi T, Yokota T, Gotoh M, Igawa Y, Seki N, Takei M, oshida M, Sugaya K, Nishizawa O
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Journal Title
BJU Int
Volume: 108(1)
Pages: 100-107
DOI
Peer Reviewed
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[Journal Article] Clinical guidelines for nocturia2010
Author(s)
Nishizawa O, Araki I, Ishizuka O, Uchimura N, Oh-oka H, Ozono S, Kakizaki H, Kasahara M, Gotoh M, Sakakibara R, Shinbo H, Sugaya K, Suzuki Y, Sone A, Takei M, Takeda M, Hirayama A, Homma Y, Yamaguchi O, Yamani shi T, Yo ko yama O, Yoshida M
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Journal Title
Int J Urol
Volume: 17(5)
Pages: 379-409
DOI
Peer Reviewed
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[Journal Article] Suppression of NF-kB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response2009
Author(s)
Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW、Paton JC and Kitamura M
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Journal Title
J Immunol
Volume: 182(11)
Pages: 7201-7211
DOI
Peer Reviewed
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[Presentation] Gene expression patterns of acid-sensing ion channels (ASICs) families in mammalian bladder2010
Author(s)
Kobayashi H, Yoshiyama M, Inuzuka H, Kira S, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Zakoji H, Tsuchida T, Araki I, Takeda M
Organizer
International Continence Society 40th Annual Meeting
Place of Presentation
Toronto, Canada
Year and Date
20100823-27
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[Presentation] Sex difference in expression profiles of acid-sensing ion channels and transient receptor potential channel v1 in the mouse urinary bladder2010
Author(s)
Kobayashi H, Yoshiyama M, Araki I, Kira S, Inuzuka H, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Kamiyama M, Kudou S, Zakoji H, Tsuchida T, Fukasawa M, Takeda M
Organizer
European Association of Urology 25th Annual Congress
Place of Presentation
Barcelona, Spain
Year and Date
20100416-20
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[Presentation] The effect of chinese herbal medicine containing aconitine on the pain relief in interstitial cystitis patients- a preliminary study2009
Author(s)
Tsuchi da T, Mi yamoto T, Yamagi shi T, Kira S, Kayanuma K, Haneda Y, Kobayashi H, Zakoji H, Araki I, Takeda M
Organizer
American Urological Association 104th annual meeting
Place of Presentation
Chicago, IL, USA
Year and Date
20090425-30
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