2011 Fiscal Year Final Research Report
Investigation for mechanisms of the metabolic syndrome due to intrauterine undernutrition and its prevention
| Project/Area Number |
21592094
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
YURA Shigeo 京都大学, 医学研究科, 非常勤講師 (60335289)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAGAWA Norimasa 三重大学, 医学系研究科, 教授 (00162321)
TATSUMI Keiji 京都大学, 医学研究科, 講師 (10324633)
FUKUHARA Ken 京都大学, 医学研究科, 講師 (00362533)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 産科学 / 妊娠 / 胎児発育障害 / 酸化ストレス / チオレドキシン / 分岐鎖アミノ酸 |
|---|
| Research Abstract |
Undernutrition in utero is closely associated with metabolic syndrome in adulthood. In the present study, we revealed that the expression of thioredoxin binding protein-2(TBP-2) in human placenta is regulated during the progression of pregnancy and dependent on oxygen condition, and is associated with physiological and pathological conditions. We also demonstrated that TBP-2 is a critical molecule that mediates glucose homeostasis during maternal undernutrition and that elevated systolic blood pressure of offspring was ameliorated by maternal ingestion of branched-chain amino acid supplemented diet during food restriction.
|
