2011 Fiscal Year Final Research Report
Analyzing how defects of Mitochondria DNA affect oocyte maturation.
| Project/Area Number |
21592117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHMICHI Masahide 大阪医科大学, 医学部, 教授 (10283764)
TERAI Yoshito 大阪医科大学, 医学部, 講師 (90278531)
TANABE Akiko 大阪医科大学, 医学部, 助教 (70454543)
HAYASHI Atushi 大阪医科大学, 医学部, 助教 (80411338)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生殖医学 |
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| Research Abstract |
SNP of AMH rather than mitochondria DNA defect might affect the infertility caused by the older age. The influence of AMH-SNP on infertility was not apparent, however, SNP of AMHR(AMHRII-482A> G、、ISV 5-6C> T, ISV10+77A> G) might cause infertility due to ovarian failure involving lower number of retrieved oocyte and fertilization rate. Especially,-482A> G polymorphysm is thought to be associated with diminished ovarian failure.
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Research Products
(19 results)
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[Journal Article] Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer2011
Author(s)
Yoshimichi Tanaka, Yoshito Terai, Akiko Tanabe, Hiroshi Sasaki, Tatsuharu Sekijima, Satoe Fujiwara, Yoshiki Yamashita, Masanori Kanemura, Masatsugu Ueda, Michio Sugita, Wilbur A. Franklin and Masahide Ohmichi
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Journal Title
Cancer Biol Ther
Volume: 11
Pages: 50-57
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[Journal Article] Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers2010
Author(s)
Tsunetoh S, Terai Y, Sasaki H, Tanabe A, Tanaka Y, Sekijima T, Fujioka S, Kawaguchi H, Kanemura M, Yamashita Y, Ohmichi M
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Journal Title
Cancer Biol Ther
Volume: 10
Pages: 1137-114
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[Journal Article] Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary2010
Author(s)
Mabuchi S, Kawase C, Altomare DA, Morishige K, Hayashi M, Sawada K, Ito K, Terai Y, Nishio Y, Klein-Szanto AJ, Burger RA, Ohmichi M, Testa JR, Kimura T.
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Journal Title
Mol Cancer Ther
Volume: 9
Pages: 2411-2422
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[Journal Article] Long-term follow-up of neoadjuvant intraarterial chemotherapy using an original four-lumen double-balloon(4L-DB) catheter for locally advanced uterine cervical cancer2009
Author(s)
Terai Y, Kanemura M, Sasaki H, Tsunetoh S, Tanaka Y, Yamashita Y, Yamamoto K, Sasaki H, Yamashita Y, Kanemura, Ohmichi M.
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Journal Title
M, Int J Clin Oncol
Volume: 14
Pages: 56-62
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[Journal Article] mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary2009
Author(s)
Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa J R, Kimura T.
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Journal Title
Clin Cancer Res
Volume: 15
Pages: 5404-5413
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