Protection against respiratory infection during neonate to infant periods by maternal intranasal immunization

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Wakayama Medical University
• Principal Investigator: HOTOMI Muneki 和歌山県立医科大学, 医学部, 講師 (90336892)
• Co-Investigator(Kenkyū-buntansha): YAMANAKA Noboru 和歌山県立医科大学, 医学部, 教授 (10136963) ; TAMURA Shinji 和歌山県立医科大学, 医学部, 講師 (10244724) ; TOGAWA Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
• Project Period (FY): 2009 – 2011
• Keywords: 耳科学

Research Abstract

Pneumococcal vaccine plays an important role in protection against pneumococcal infections. However, infants exhibit impaired innate and adaptive immune responses, which result in insufficient induction of anti-pneumococcal antibody. The current study demonstrated the highly induction of anti-pneumococcal specific antibody among offspring delivered from mother mice immunized with pneumococcal surface protein A. This result would conduce a novel strategy of the development of pneumococcal vaccine.

Research Products

• [Journal Article] Maternal immunizat ion with pneumococcal surface protein A protects against pneumococcal infectio ns among derived offspring (2011)
  • Author(s): Kono M, Hotomi M, Hollingshead SK, Br iles DE, Yamanaka N
  • Journal Title: PLoS One Volume: 6(10) Pages: e27102
  • Peer Reviewed
• [Journal Article] Protection of pneu mococcal infection by maternal intranas al immunization with pneumococcal surfa ce protein A (2011)
  • Author(s): Hotomi M, Kono M, Hollingshead SK, Br iles DE, Yamanaka N.
  • Journal Title: Adv Otorhinolaryngol Volume: 72 Pages: 121-125
• [Presentation] Induction of specific immune responses against S. pneumoniae by maternal immunization with pneumococcal surface protein A(PspA) (2011)
  • Author(s): Kono M, Hotomi M, et al
  • Organizer: 10th International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-06-08
• [Presentation] Protection of pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A(PspA) (2010)
  • Author(s): Hotomi M, et al
  • Organizer: The 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Asahikawa, Japan
  • Year and Date: 2010-07-08
• [Presentation] Production of IL-17A by splenocytes of offspring delivered from PspA-immunized mother mice (2009)
  • Author(s): Kono M, Hotomi M, et al
  • Organizer: 6th Extraordinary International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-08
• [Presentation] Protection of pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A(PspA) (2007)
  • Author(s): Katsurahara T, Hotomi M, et al
  • Organizer: 9th International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: St. Pete Beach, USA
  • Year and Date: 2007-06-04