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2011 Fiscal Year Final Research Report

Prevention of dementia by the recovery of the mastication

Research Project

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Project/Area Number 21592448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthetic dentistry
Research InstitutionOkayama University

Principal Investigator

HARA Tetsuya  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60238160)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Tohru  就実大学, 薬学部, 教授 (30243463)
KODAMA Chie  岡山大学, 医歯薬学総合研究科, 助教 (50444667)
Co-Investigator(Renkei-kenkyūsha) KAWATA Kazumi  岡山大学, 歯学部, 非常勤研究員 (10457228)
MINAGI Shogo  岡山大学, 医歯薬学総合研究科, 教授 (80190693)
Project Period (FY) 2009 – 2011
Keywords咀嚼 / 記憶 / 海馬 / 認知症 / 遺伝子 / DNAアレイ
Research Abstract

The memory related gene expression in the rat hippocampus was analyzed by using the DNA microarray method. The gene expression of Trh and Tnxa increased when studying, and that of Nnat and S100a9 decreased. The number of errors of radial maze in the extraction group was more than that of the denture group and the control group. The time course of these 4 gene expression was observed by real-time PCR method. The gene expression of Tnxa Nnat and S100a9 showed the consistency with behavioral experiment result.

  • Research Products

    (4 results)

All 2012 2011 2010

All Presentation (4 results)

  • [Presentation] Memory-related gene expression in the rat hippocampus by the learning2012

    • Author(s)
      Iida S, Araki D, Hara T, Kuroda C, Oka M, Kurozumi A, Kawata K, Sakamoto S, Miyazaki T, Minagi S
    • Organizer
      American Association for Dental Research
    • Place of Presentation
      Tampa, USA
    • Year and Date
      2012-03-22
  • [Presentation] 咬合支持回復時の空間認知能に対する分散学習の影響2011

    • Author(s)
      原哲也, 黒住明正, 坂本隼一, 飯田祥与, 荒木大介, 黒田知沙, 岡森彦, 白井肇, 森慎吾, 衣田圭宏, 皆木省吾
    • Organizer
      日本老年歯科医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-15
  • [Presentation] Spaced Training Facilitates Long-term Memory Retention in Molarless Rats2011

    • Author(s)
      Hara T, Kurozumi A, Sakamoto S, Kuroda C, Oka M, Iida S, Araki D, Minagi S
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-20
  • [Presentation] Influence of Molar Loss on Gene Expression in Hippocampus2010

    • Author(s)
      Hara T, Kawata K, Kurozumi A, Oka M, Kuroda C, Shimazu-Kodama C, Sakamoto S, Minagi S
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-17

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Published: 2013-07-31  

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