2012 Fiscal Year Final Research Report
Multi-functionality and structure development of thalidomide
| Project/Area Number |
21790107
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YACHIDE Tomomi 東京大学, 分子細胞生物学研究所, 技術職員 (20401284)
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| Project Period (FY) |
2009 – 2012
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| Keywords | ケミカルバイオロジー |
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| Research Abstract |
I investigated the molecular mechanism of action of thalidomide andits metabolites, and cell signaling of biologically active derivatives of thalidomide. In addition, some biologically active compounds, such as nuclear receptor agonists/antagonists and enzyme inhibitors, have been created by structural development ofthalidomide and its derivatives. Based on these studies, I proved that thalidomide is usefulas a novel multi-template for development of various kinds of biologically activecompounds.
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[Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6 Hdibenz[b,e]azepin-6-one skeleton.2012
Author(s)
Atsushi Aoyama, Kaori Endo-Umeda, Kenji Kishida, Kenji Ohgane, Tomomi Noguchi- Yachide, Hiroshi Aoyama, Minoru Ishikawa, Hiroyuki Miyachi, Makoto Makishima and Yuichi Hashimoto
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Journal Title
J. Med. Chem
Volume: 55
Pages: 7360-7377
Peer Reviewed
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