2011 Fiscal Year Final Research Report

Studies on the roles of Periplakin in liver

Research Project

Project/Area Number	21790272
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	Kyoto University
Principal Investigator	ITO Shinji 京都大学, 医学研究科, 助教 (50362512)
Project Period (FY)	2009 – 2011
Keywords	肝臓 / 遺伝子発現 / 恒常性維持
Research Abstract	Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.