2011 Fiscal Year Final Research Report
Studies on the roles of Periplakin in liver
Project/Area Number |
21790272
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
ITO Shinji 京都大学, 医学研究科, 助教 (50362512)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 肝臓 / 遺伝子発現 / 恒常性維持 |
Research Abstract |
Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.
|
-
[Journal Article] Relevant use of Klotho in FGF19subfamily signaling system in vivo2010
Author(s)
Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji ItoKen-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito
-
Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107(4)
Pages: 1666-1671
DOI
Peer Reviewed
-