2010 Fiscal Year Final Research Report
Basic research of photodynamic therapy for the malignant glioma using a newly photosensitizer.
| Project/Area Number |
21791346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Gunma University |
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Principal Investigator |
SUGAWARA Kenichi Gunma University, 医学部, 助教 (50375573)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 悪性神経膠腫 / 光線力学療法 / ポルフィリン誘導体 |
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| Research Abstract |
Various photosensitizers are used in a photodynamic therapy for human malignant gliomas. However, no satisfactory results are obtained because of low cytotoxicities. We experimented using a porphyrin derivative by silylation, which increased production efficiency of singlet oxygen with cytotoxicity compared with other photosensitizers. Photodynamic therapy of human malignant gliomas using this newly photosensitizer may be possible.
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