2010 Fiscal Year Final Research Report
Molecular mechanisms underlying dietary restriction-induced longevity
| Project/Area Number |
21870014
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Animal physiology/Animal behavior
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HONJOH Sakiko Kyoto University, 生命科学研究科, 特定研究員 (30551379)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 老化 / 線虫 / 食餌制限 |
|---|
| Research Abstract |
We found that sensory organs play important roles in life span regulation in the nematode C. elegans. We previously reported that intermittent fasting (IF), a kind of dietary restriction, extends the life span of C. elegans by more than 60%. We found that mutant strains with various defects in sensory organ development responded to IF to a lesser extent than wild type animals. The results show that sensory perception mediates IF-induced longevity.
|
-
-
[Journal Article] The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans2010
Author(s)
Okuyama, T., Inoue, H., Ookuma, S., Satoh, T., Kano, K., Honjoh, S., Hisamoto, N., Matsumoto, K., Nishid, E.
-
Journal Title
Journal of biological chemistry Vol.285
Pages: 30274-30281
Peer Reviewed
-
-
