2023 Fiscal Year Final Research Report

The establishment of intraocular cytology: Seamless research from basic to clinical applications.

Research Project

PDF

Project/Area Number	21H03095
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 56060:Ophthalmology-related
Research Institution	Kagoshima University
Principal Investigator	Sakamoto Taiji 鹿児島大学, 医歯学域医学系, 教授 (10235179)
Co-Investigator(Kenkyū-buntansha)	原博満鹿児島大学, 医歯学域医学系, 教授 (20392079) 寺崎寛人鹿児島大学, 医歯学域鹿児島大学病院, 講師 (20746888) 橋口照人鹿児島大学, 医歯学域医学系, 教授 (70250917) 渡邊睦鹿児島大学, 理工学域工学系, 教授 (50325768)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	硝子体 / 脈絡膜 / 光干渉断層計 / 人工知能 / 画像診断
Outline of Final Research Achievements	The latest research on studies from the vitreous to the choroid has emphasized applying findings from years of vitreous studies to clinical medicine. Previously, only basic fundus photographs were taken, but now, a variety of data can be obtained using diverse laser lights. This led to the establishment of a technique for early detection of retinal diseases using fundus photographs focusing on biomarkers. Artificial intelligence was integrated into this process, addressing its transparency issues in diagnosis. Additionally, a wayfinding AI algorithm using entropy was devised for OCT and image diagnosis of the retina, implemented in domestically produced medical devices. Analysis of choroidal expansion in ultra-widefield images was also conducted, now possible due to ultra-widefield OCT, facilitating the quantification of vascular volume near peripheral vortex veins. This research period significantly contributed to the practical application of previous findings in clinical medicine.
Free Research Field	記入ください
Academic Significance and Societal Importance of the Research Achievements	過去20年間、眼球内生物学研究として眼内のホメオスタシスについての研究を行ってきた。ただし、その成果の実用化は困難であった。そこで、最終年度は人工知能を用いて、その実用化を図った。その結果、人工知能においては、思考過程が極めて人間に類似していることがわかった。つまり、人工知能が迷う点は人間も迷うのである。そのことを理解してから、OCT画像診断における問題点を描出する人工知能や、眼球最周辺の血管構造を生体下で定量する器械の開発に国産医療機器メーカーとともに取り組み成功した。