2023 Fiscal Year Final Research Report

Impact of orofacial function on recovery from dysphagia caused by cerebrovascular disorders

Research Project

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Project/Area Number	21H03128
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 57050:Prosthodontics-related
Research Institution	Niigata University
Principal Investigator	Inoue Makoto 新潟大学, 医歯学系, 教授 (00303131)
Co-Investigator(Kenkyū-buntansha)	辻村恭憲新潟大学, 医歯学系, 准教授 (00548935) 那小屋公太新潟大学, 医歯学系, 助教 (10806491) 照沼美穂新潟大学, 医歯学系, 教授 (50615739) 真柄仁新潟大学, 医歯学総合病院, 講師 (90452060) 吉原翠新潟大学, 医歯学系, 助教 (70882330)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	歯科 / 嚥下 / モデル動物 / 脳梗塞 / 外頸動脈 / カリウムイオン / 顎二腹筋後腹
Outline of Final Research Achievements	In the middle cerebral artery occlusion model, no obvious swallowing disorders were observed, but ligation of the ipsilateral external carotid artery during the preparation significantly reduced the peak of the digastric reflex, and there was a large variability in the effects on muscle activity in the innervated area. This suggests compensation for blood supply from collateral circulation of the internal carotid artery, which varies greatly among individuals. Potassium ion was suggested to be the most effective peripheral stimulation during recovery from stroke, and the involvement of KATP channels and Kir3.1 channels localized in the nodose ganglion and peripheral area was suggested. The activity patterns of the digastric muscle and the sternohyoid muscle and direct projections from the swallowing central pattern generator was clarified, which have not been reported previously.
Free Research Field	摂食嚥下障害学
Academic Significance and Societal Importance of the Research Achievements	摂食嚥下障害の原因疾患として最も多いのは脳血管疾患であり，ことに中大脳動脈の梗塞症例では摂食関連の感覚運動領域の麻痺に伴い摂食嚥下障害が遷延する．これに対して，多くの臨床報告がリハビリテーション効果を示唆しているものの，改善をもたらすプロセスについては未だ科学的根拠は不明である．今回の基礎研究は，脳血管モデル動物を使用する際に留意すること，リハビリテーションの過程でいかなる刺激が有効となり得るか，またリハビリテーション効果を明らかにする上でいかなる運動機能や筋を評価するべきかについての基礎データを提供できたという点でその意義は高いと言える．