Development of a novel boron agent for the treatment of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Okayama University
• Principal Investigator: NISHIMORI HISAKAZU 岡山大学, 医学部, 客員研究員 (70756064)
• Co-Investigator(Kenkyū-buntansha): 藤村 篤史 岡山大学, 医歯薬学域, 研究准教授 (10771082) ; 前田 嘉信 岡山大学, 医歯薬学域, 教授 (60403474)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ホウ素中性子捕捉療法 / 同種造血幹細胞移植 / 閉塞性細気管支炎

Outline of Final Research Achievements

We investigated the usefulness of boron neutron capture therapy (BNCT) as a new treatment for bronchiolitis obliterans, a pulmonary complication after allogeneic hematopoietic stem cell transplantation. We conducted research on a novel boron formulation OKD-001 and published a paper demonstrating that its efficacy differs greatly when its subcellular localization in BNCT is taken into account. We also focused on gadolinium neutron capture therapy (GNCT), and conducted research to estimate its molecular characteristics compared to BCNT, which was submitted for publication.

Free Research Field

造血細胞移植

Academic Significance and Societal Importance of the Research Achievements

同種造血幹細胞移植後の肺合併症である閉塞性細気管支炎に対する治療選択肢が少ない中、ホウ素中性子捕捉療法やガドリニウム中性子補足療法が全く新しい作用機序による治療法として確立すれば、より多くの同種移植患者さんを救うことができるため、社会的意義は大きいと考えます。また、学術的にも新治療法として臨床試験などの更なる研究が行われ、新しいエビデンスの創出が期待されます。