2023 Fiscal Year Final Research Report
Trans-Omics approach to understand the pathogenesis of H. pylori infected and uninfected gastric cancer.
| Project/Area Number |
21K08010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
塚本 善之 大分大学, 医学部, 助教 (00433053)
山岡 吉生 大分大学, 医学部, 教授 (00544248)
赤田 純子 大分大学, 医学部, 助教 (30346548)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ピロリ菌感染症 / 胃癌 / 次世代シーケンス / 胃オルガノイド / RNA-Seq / メタボロミクス |
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| Outline of Final Research Achievements |
This study isolated and identified a novel bacterium involved in gastric cancer pathogenesis by a mechanism distinct from Helicobacter pylori (H. pylori). Using gastric organoids, which more closely mimic the in vivo environment, it was further shown that this bacterium induces DNA double-strand breaks, which trigger gastric cancer pathogenesis, via the induction of reactive oxygen species and also suppresses the DNA damage response pathway. It has also been suggested that the differences in the attachment mechanism due to the genotype of the outer membrane protein of H. pylori affect the mucosal environment of the stomach and influence the colonization and composition of other bacterial flora that may be involved in the pathogenesis of gastric and duodenal diseases.
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| Free Research Field |
細菌学
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| Academic Significance and Societal Importance of the Research Achievements |
ピロリ菌は、胃癌や消化性潰瘍の原因微生物として広く認知され、現在、国内では積極的な内視鏡検査と除菌治療が進められている。一方で、ピロリ菌未感染胃癌や除菌後胃癌など、これまで注目されてこなかった病態の存在が浮き彫りになり、科学的な検証が必要である。本研究では、ピロリ菌以外の病原微生物の存在やその病原性を明らかにし、ピロリ菌が胃内のその他細菌叢の構成をどのように制御しているのかを実験的に示すことができた。今後、関連する胃・十二指腸疾患の臨床疫学データの蓄積が進み、予防策の立案に繋げるなど社会還元を期待する。
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