2023 Fiscal Year Final Research Report
Analysis of D-DT Function in the Pathophysiology of Skin Disorders and Its Implications for Novel Therapeutic Approaches
| Project/Area Number |
21K08342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
牧野 輝彦 富山大学, 学術研究部医学系, 准教授 (90359711)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | D-ドパクロムトートメラーゼ / MIF / アトピー性皮膚炎 / 乾癬 / 強皮症 / 炎症 |
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| Outline of Final Research Achievements |
Atopic dermatitis, an allergic dermatitis, psoriasis, an inflammatory skin disease, and scleroderma, an autoimmune disease, are all multifactorial diseases in which genetic predisposition and environmental factors are involved. Recently, it has been reported that D-dopachrome tautomerase (D-DT), a functional homolog of the macrophage migration inhibitory factor, may function as a symptomatic cytokine. In this study, the biological function of D-DT was analyzed in the pathophysiology of autoimmune diseases such as atopic dermatitis, psoriasis, and scleroderma using D-DT Tg mice in comparison to WT mice. It was clinically and histologically confirmed that the inflammatory response was predominantly higher in atopic dermatitis and psoriasis mouse models using D-DT Tg mice than in WT mice. It was confirmed that the dermal thickness and cell infiltration of D-DT Tg mice were stronger than those of WT mice with scleroderma model mice.
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| Free Research Field |
医学
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| Academic Significance and Societal Importance of the Research Achievements |
我々の研究室では，様々な疾患におけるMIFの役割について多くの知見を有しており，さらにMIFのtransgenic (Tg)マウス，MIFノックアウトマウス，D-DT Tgマウスを所有している．これらのマウスを用いて，アトピー性皮膚炎，乾癬，強皮症におけるD-DTの機能をMIFと異同を詳細に解析できるのは，我々のグループのみである．このことから本研究の学術的意義は高い．
本研究から得られる知見は他のアレルギー疾患，炎症性疾患，自己免疫性疾患の病態の解明にも繋がることが期待され，それらの疾患の治療薬開発にも貢献する．以上より，本研究は臨床医学・基礎医学の両方の発展に大きく寄与する研究と考える．
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