2023 Fiscal Year Final Research Report
Development of new photo dynamic therapy for peritoneal dissemination of gastric cancer
| Project/Area Number |
21K08782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
衛藤 剛 大分大学, 医学部, 准教授 (00404369)
白坂 美哲 大分大学, 医学部, 客員研究員 (40837746)
大嶋 佑介 富山大学, 学術研究部工学系, 准教授 (10586639)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 光線治療 / パルスレーザー / 腹膜播種 |
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| Outline of Final Research Achievements |
In this study, we developed a light source to improve the cell-killing effect of near-infrared ultrashort pulsed laser irradiation on gastric cancer peritoneal seeding lesions, aiming at the practical application of pulsed laser phototherapy that can treat peritoneal seeding lesions by endoscopy.
First, the principle of ALA-PDT/PDD by photon excitation was demonstrated by performing laser irradiation of gastric cancer cell lines using an ultrashort pulsed laser, which showed a cell-killing effect. Furthermore, a compact fiber laser system jointed with a microscope was constructed.
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| Free Research Field |
消化器外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により，光子励起によるALA/PDDの効果が確認でき，また顕微鏡とジョイントした小型ファイバレーザーシステムを構築したことで，腹膜播種という広範囲かつ深部ですべてを肉眼的に同定することが難しい病変に対して抗癌剤治療よりも直接的に治療を行える治療法の開発につながる可能性がある．
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