Functional evaluation of bioabsorbable small-caliber vascular graft in a diabetic rat model to achieve a practical use

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Kikuchi Yuta 旭川医科大学, 医学部, 助教 (80882711)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Diabetes / Pathological condition / PCL graft / Insulin treatment / Endothelialization

Outline of Final Research Achievements

In this study, we evaluated the performance of a PVA-PCL graft with a diameter of 1 mm in a DM rat model. We demonstrated that DM disrupted the function of the PVA-PCL graft and that NPH insulin treatment rescued this deterioration. Various nanofiber grafts have been developed and tested in healthy animal models. Our results indicated that the performance of these nanofiber grafts can alter in disease conditions. Therefore, it is important to clarify the mechanisms underlying how disease conditions change nanofiber vascular graft performance and develop strategies for overcoming these challenges. Thus, our study highlighted the importance of using a model that more closely reflects the cases encountered in clinical practice, considering patients with comorbidities and the related treatments, to the end of developing clinically applicable small-diameter vascular grafts.

Free Research Field

小口径人工血管

Academic Significance and Societal Importance of the Research Achievements

下肢末梢血管や冠動脈のような小口径血管バイパス術において、自家血管が唯一のバイパスグラフトとなるが、患者背景により、その性状や長さに制限があり、長期開存可能な小口径人工血管の開発が期待されている。健常動物モデルにおいて多くの試験が行われ、一部で良好な成績が報告されているが、臨床において多くの患者が糖尿病のような併存疾患を有している。本研究は糖尿病および糖尿病治療が小口径人工血管に及ぼす影響について検討し、臨床応用に向けた、病態下および病態治療下における人工血管試験の重要性を再認識するものである。