A non-invasive method to detect sinoatrial node function in human

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Saitama Medical University
• Principal Investigator: Tsutsui Kenta 埼玉医科大学, 医学部, 客員准教授 (30534284)
• Co-Investigator(Kenkyū-buntansha): 住友 直方 埼玉医科大学, 医学部, 教授 (50231379) ; 千本松 孝明 埼玉医科大学, 医学部, 教授 (70216563) ; 森 仁 埼玉医科大学, 医学部, 講師 (50900148) ; 池田 礼史 埼玉医科大学, 医学部, 准教授 (80789529) ; 加藤 律史 埼玉医科大学, 医学部, 教授 (10286049)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 心臓老化 / 心拍揺らぎ / 老化性心不全

Outline of Final Research Achievements

The present study examines the effects of aging on sinoatrial node (SAN) function, analyzing the interplay between the autonomic nervous system (ANS) and intrinsic mechanisms. We recorded electrocardiograms from young (n=16) and adult (n=23) patients under anesthesia and after ANS blockade. We identified distinct "signatures" of ANS and intrinsic mechanisms on beat interval variability (BIV), finding age-related changes in their contributions. In young patients, intrinsic mechanisms largely influence long-term BIV, whereas in adults, both ANS and intrinsic mechanisms affect both short- and long-term BIV. Anesthesia impacts ANS function differently across age groups.

Free Research Field

心臓電気生理学

Academic Significance and Societal Importance of the Research Achievements

この研究で得られたデータをもとに、薬剤の投与なしで、10分前後の心拍の揺らぎから心臓の加齢状態に関する洞察が得られる可能性が見出された。「心臓老化の非侵襲的診断」開発手法の確立へ向けて着実に前進することができた。