relationship between Hippo-Yap circuit activity and hypoactive bladder leading to fibrosis of the bladder.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: University of Yamanashi
• Principal Investigator: Ihara Tatsuya 山梨大学, 大学院総合研究部, 医学研究員 (90622407)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 膀胱線維化 / 低活動膀胱

Outline of Final Research Achievements

Ex vivo mouse bladders were cultured in the medium under the stretched state. fibrosis was observed to progress over time in the bladder. Fibrosis was suppressed when the bladder was treated with an inhibitor of mechanoseonsor
receptors (GsMTx4). As fibrosis progressed, TGF-β1, a fibrosis-promoting factor, also increased in the culture medium, however TGF-β1 decreased under the GsMTx4 treatment. Thus, it is considered that the persistent stretching of the bladder promotes fibrosis, which may be the cause of the condition leading to a underactive bladder, however suppression of the mechanosensor receptor may delay the progression of the condition.

Free Research Field

排尿障害

Academic Significance and Societal Importance of the Research Achievements

膀胱出口部閉塞による残尿増加などは膀胱壁の慢性的な伸展刺激を生じさせている。機械センサーであるPiezo1などが恒常的に活性化されている状態でありこれらが膀胱壁の線維化を促進させ膀胱過活動や低活動を誘発させると考えられる。
将来的にも増加が予想されるこれら膀胱機能低下に対する新規の治療戦略や新規治療薬の創生に結び付け、高齢化社会のQOL向上に貢献したいと考える。