Cutting-edge Research on Soft Tissue Integration around Zirconia Dental Implants

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Showa University
• Principal Investigator: Fuminori Iwasa 昭和大学, 歯学部, 客員教授 (60297025)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ジルコニアインプラント / 軟組織付着 / インプラント周囲組織 / セリア安定化ジルコニア／アルミナナノ複合体

Outline of Final Research Achievements

The proposed research investigated the attachment ability of human gingival fibroblasts (HGF-1) and human oral epithelial cells (JE-1) to the surface of ceria-stabilized zirconia/alumina nanocomposites (Ce-TZP/Al2O3). In the culture experiments using HGF-1, the cells were cultured for 7 days on Ce-TZP/Al2O3 substrates with machined (Ra = 0.9) and mirror-polished (Ra = 0.02) surfaces. The results showed that the expression system (adhesion, proliferation, and morphology) of HGF-1 was enhanced on the mirror-polished surface. In the final year, the main experiment involved implanting Ce-TZP/Al2O3 mini-implants in rats and evaluating the soft tissue seal at the mucosal penetration site. The academic and social significance of these research findings will be discussed

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

長期に安定したインプラント治療を目指すにあたって、インプラント周囲炎への対策は大きな課題である。すなわち高度な軟組織封鎖性を有するインプラントの開発が重要である。粘膜貫通部の適切な表面性状の探索は、インプラント周囲炎に抵抗性を持つインプラントの開発に向けた研究基盤を確立できると確信している。