2023 Fiscal Year Final Research Report
Clinical application of known lifestyle-related disease susceptibility genetic factors in consideration of their interrelationship with lifestyle factors
| Project/Area Number |
21K10488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | Hirosaki University |
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Principal Investigator |
DAIMON Makoto 弘前大学, 医学研究科, 客員研究員 (20241698)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 遺伝子環境相互作用 / 分子疫学 / 生活習慣病 / 糖尿病 / 遺伝子多型 |
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| Outline of Final Research Achievements |
Lifestyle-related diseases are multifactorial diseases involving various lifestyle and genetic factors, and thus their interactions should have substantial influence on their disease status. Therefore, we aimed to search for disease susceptibility genetic factors based on detailed lifestyle data and to develop a method that would be useful in actual clinical practice. Results during the study period: 1) Cohort follow-up: We continued and expanded data of our study cohort, and conducted various analyses using the data and proposed a new risk group that cannot be determined by glucose tolerance alone, based on an integrated analysis of background factors for the development of diabetes mellitus. 2) Association analysis using genetic factors: We analyzed 18 known gene polymorphisms and their combinations, and the effects of nutritional status on diabetes, and found that several gene polymorphisms are associated with diabetes in a nutritional intake-dependent manner.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
遺伝情報を利用した個別化医療が近い将来導入されると言われて20年以上経つが、少なくとも生活習慣病の治療では、実臨床に導入される状況にはない。これまで多くの疾患感受性遺伝因子が報告されて来たが、それらを統合しても十分に生活習慣病のリスクを説明できない事が、その理由だが、私達は、生活習慣との相互作用を考慮せず解析している事がその要因と考え、種々生活習慣依存性に疾患感受性となる遺伝因子の解析を進めて来た。今回の研究は、これら研究を発展させ、既報の疾患感受性遺伝因子を対象として協調して働く生活習慣（環境）因子を明らかにするもので、その成果は実臨床で役立つ情報を提供し、個別化医療へ繋がる物と思われる。
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