Development of a new anti-cancer seed based on the cell-line selective anti-proliferative activity of oscillatoxin F

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K14793
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38040:Bioorganic chemistry-related
• Research Institution: Kagawa University
• Principal Investigator: Hanaki Yusuke 香川大学, 農学部, 助教 (70897818)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: Oscillatoxin / 抗がん剤 / 天然物

Outline of Final Research Achievements

In this study, it was found that oscillatoxin F showed a cell-line selective anti-proliferative activity dependent on the structure of A-ring moiety. In addition, reducing the molecular hydrophobicity was suggested to improve the anti-proliferative activity. We developed a new synthetic route to introduce various functional groups to the A-ring moiety and a biotin-tag to the side chain. These studies may contribute to developing superior anti-tumor analogs and identifying target molecules related to the cell line-selective anti-proliferative activity.

Free Research Field

生物有機化学

Academic Significance and Societal Importance of the Research Achievements

近年、国内外の複数の研究グループによってシアノバクテリアから数多くのoscillatoxin類縁体が単離され、多様な生物活性を有することが報告されている。本研究では、oscillatoxin類の構造活性相関の一端を明らかにするとともに作用機構を明らかにするための基盤となる結果が得られた。今後、oscillatoxin類のユニークな生物活性の解析に役立つものと考えられる。