2023 Fiscal Year Final Research Report
Analysis of association in gastric carcinogenesis, genetic alteration, and H. pylori infection with cell culture system
| Project/Area Number |
21K15972
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 遺伝子変異解析 / 発癌 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the detailed mechanism of carcinogenesis in gastric epithelial cells, by inducing genetic alterations of driver genes in cultured gastric cells. So far, almost 60 gastric tissues have been collected by different patients and on culturing. Analysis on genetic alterations on the primary tissue and gastric crypts/pits revealed that the genetic alterations in the gastric stem cells accumulate with the aging of the patients, and some of the known driver genes of gastric cancers were frequently mutated, compared to the gastric cancer tissue, in the non-tumorous gastric epithelial cells.
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| Free Research Field |
人体病理学
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| Academic Significance and Societal Importance of the Research Achievements |
胃癌の人口あたりの罹患率は98.5 例、死亡率は34.3 人（いずれも人口10万対）とされており、その発生メカニズム、治療標的の発見が待たれている。疫学的にはピロリ菌感染による腸上皮化生と胃癌発生に有意な相関があることが知られていたが、その詳細はわかっていなかった。本研究の遂行により腸上皮化生と胃粘膜上皮における遺伝子異常の蓄積に有意な相関があること、遺伝子異常のパターンは非癌部腸上皮化生領域と癌部領域とで有意な差があることがあきらかになった。このメカニズムを解明していくことで、胃癌の進展・発症予防に資する知見を得られることが期待される。
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