Why does exercise training prevent endothelial dysfunction after acute resistance exercise?

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17553
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Chukyo University
• Principal Investigator: Morishima Takuma 中京大学, 教養教育研究院, 准教授 (60771706)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: レジスタンス運動 / 血管内皮機能 / FMD / 一酸化窒素 / エンドセリン-1 / 運動トレーニング

Outline of Final Research Achievements

Highly trained individuals with a habit of high-intensity exercise do not experience a decline in endothelial function following acute resistance exercise. This study was conducted to elucidate the physiological mechanisms underlying this phenomenon. The summary of the research findings includes the following points.
(1)Even in sedentary individuals, temporarily enhancing the nitric oxide (a vasodilator) bioavailability by supplementation prevents the endothelial dysfunction following acute resistance exercise. (2)There is no difference in the response of endothelial-derived substances to acute resistance exercise between those with and without an exercise habit. (3)Unlike sedentary individuals, individuals with a habit of exercise experience an improvement in microvascular function after acute resistance exercise.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、なぜ運動トレーニングは一過性のレジスタンス運動後における血管内皮機能の低下を予防するのか、その生理学的メカニズムの一端を示した点において学術的価値が高い。また、社会的意義としては、「一過性のレジスタンス運動後における血管内皮機能の低下を予防する」というこれまでとは異なる視点での運動トレーニングの効果を示した点が挙げられる。