The involvement of TRPV1 in bone metabolism in a CRPS model mouse

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K20980
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Baba Kazuhiko 産業医科大学, 医学部, 診療助教 (90910183)
• Project Period (FY): 2021-08-30 – 2024-03-31
• Keywords: CRPS / 骨粗鬆症 / TRPV1 / TRPV4 / ノックアウトマウス

Outline of Final Research Achievements

We investigated the involvement of TRPV1 and TRPV4 in CRPS-induced hyperalgesia and bone loss in a mouse model of complex regional pain syndrome (CRPS). The results showed that in wild-type and TRPV1-knockout mice, femur trabecular bone volume, trabecular number, and trabecular thickness on the affected side of the CRPS model were significantly reduced and the trabecular separation was significantly increased compared to each sham-operation group, while no significant changes were observed in the TRPV4-knockout mice. The results suggest that TRPV4 may be a potential therapeutic target for CRPS-induced bone loss.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

CRPSの痛覚過敏および骨量減少の病的状態下において、TRPV1およびTRPV4がどのように関与しているのかについては不明な点が多い。本研究課題では、TRPV1ノックアウトマウスおよびTR PV4ノックアウトマウスを用いてCRPSモデルマウスを作成し、TRPV4ノックアウトマウスにおいて、CRPSに伴う骨量減少を認めなかった。今後TRPV4がCRPSの骨量減少に対する治療選択肢の一つとなる可能性があり、これらの知見に社会的意義があると考える。