2012 Fiscal Year Final Research Report
Development of higher cognitive functions based on the subcortical brain areas
| Project/Area Number |
22240051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional social brain science
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| Research Institution | University of Toyama |
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Principal Investigator |
NISHIJO Hisao 富山大学, 大学院・医学薬学研究部(医学), 教授 (00189284)
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| Co-Investigator(Kenkyū-buntansha) |
HORI Etsuro 富山大学, 大学院・医学薬学研究部(医学), 准教授 (90313600)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 上丘 / 視床枕 / 扁桃体 / 社会行動 / 脳発達 / 自閉症 |
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| Research Abstract |
This study investigated a role the extrageniculate visual system （subcortical system) consisting of retina → superior colliculus （SC) → pulvinar → amygdala in the brain development. The neurophysiological results indicated that neurons in these areas responded to social stimuli including faces and eye contact with short response latencies. The lesion of the SC induced autistic-likedeficits in monkeys. Furthermore, neuroanatomical studies using various kinds of animal models of autisms indicated that the number of parvalbumin-positive （GABAergic) neurons was decreased in these areas.
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[Journal Article] Impact of perinatal dioxin exposure on infant growth: a cross-sectional and longitudinal studies in dioxin- contaminated areas in Vietnam.2012
Author(s)
Nishijo M, Tai PT, Nakagawa H, Maruzeni S, Anh NTN, Luong HV, Anh TH, Honda R, Morikawa Y, Kido T, Nishijo H
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Journal Title
PLoS ONE
Volume: 7(7)
Pages: e40273
DOI
Peer Reviewed
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.2011
Author(s)
Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
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Journal Title
Hippocampus
Volume: 21
Pages: 678-687
Peer Reviewed
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[Journal Article] Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice.2011
Author(s)
Nguyen PTH, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
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Journal Title
PLoS ONE
Volume: 6(3)
Pages: e18004
Peer Reviewed
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[Presentation] Schizophrenia and autism-like symptom in Platelet-Derived Growth Factor Receptor-β Gene Knockout mice.2011
Author(s)
Nakamura T, Phuong THN, Hori E, Urakawa S, Wano T, Juanjuan Z, Ruixi L, Nguyen DB, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, and Nishijo H.
Organizer
The 6th International Conference of Neurons and Brain Diseases
Place of Presentation
Toyama.
Year and Date
2011-08-05
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[Book] Organohalogen Compounds2012
Author(s)
Nishijo M, Tai PT, Nui NM, Anh NTN, Hai NM, Maruzeni S, Nghi TN, Phuong PT, Nishijo H, Anh TH, Luong HV, Kido T, Okamoto R, Son LK, Nakagawa H
Total Pages
1332-1335
Publisher
Effects of dioxins exposure on social emotional behavior of children living in a hot spot area, Vietnam.
