2012 Fiscal Year Final Research Report
Predictors of autism including low birth weight and social cognitive impairment: a longitudinal epidemiological study
| Project/Area Number |
22249045
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
TAKEI Noriyoshi 浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Katsuaki 浜松医科大学, 子どものこころの発達研究センター, 准教授 (00285040)
TSUCHIYA Kenji 浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
MATSUMOTO Kaori 浜松医科大学, 子どものこころの発達研究センター, 助教 (20447808)
IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 助教 (30415088)
SHIMMURA Chie 浜松医科大学, 子どものこころの発達研究センター, 特任研究員 (30529467)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 自閉症 / コホート研究 / 疫学 / 予測 |
|---|
| Research Abstract |
No study has succeeded in establishing very early precursors for predicting autism spectrum disorder (ASD). To establish such precursors in behavioural as well as social context suggested in literature, we founded a birth cohort study in November, 2007: Hamamatsu Birth Cohort Study for Mothers and Children (HBC Study), in which more than 1,200 mother-and-infant dyads are involved and are currently followed-up. Among the participating children followed-up by the age of 32 months (N=549), 24 were diagnosed to have a consensus diagnosis of ASD. In the analyses using mixed modeling , we found that developmental milestones including sitting, response to joint attention, appropriate response to “Give it to me”, optical righting reflex, manipulative use of both hands, at the age of 10 months and14 months, are predictive of ASD diagnosis at the age of 32 months. Then, we combined these precursors to formulate a diagnostic algorithm, and resulted in sensitivity of 88% and specificity of 83%. We concluded that, using 5 developmental milestones, which are not confined in the well-known socialcognition domain, early predictive diagnosis of ASD at the age of around 1 year is possible.
|
-
[Journal Article]2013
Author(s)
Tsuchiya KJ, Matsumoto K, Yagi A, Inada N, Kuroda M, InokuchiE, Koyama T, Kamio Y, Tsujii M, Sakai S, Mohri I, Taniike M, Iwanaga R, Ogasahara K, Miyachi T, Nakajima S, Tani I, Ohnishi M, Inoue M, Nomura K, Hagiwara T, Uchiyama T, Ichikawa H, Kobayashi S, Miyamoto K, Nakamura K, Suzuki K, Mori N, Takei N.
-
Journal Title
Journal of Autism and Developmental Disorders
Volume: 43(3)
Pages: 643-662
-
[Journal Article]2013
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N
-
Journal Title
JAMA Psychiatry
Volume: 70
Pages: 49-58
-
[Journal Article]2013
Author(s)
Larsen JI, Andersen UA, Becker T, Bickel GG, Bork B, Cordes J, Frasch K, Jacobsen BA, Jensen SOW, Kilian R, Lauber C, Mogensen B, Nielsen JA, Rossler W, Tsuchiya KJ, Uwakwe R, Munk-Jorgensen P
-
Journal Title
Australian and New Zealand Journal of Psychiatry
Volume: 47(3)
Pages: 250-258
-
[Journal Article]2012
Author(s)
Takahashi S, Tsuchiya KJ, Matsumoto K, Suzuki K, Mori N, Takei N
-
Journal Title
Maternal & Child Health Journal
Volume: 16
Pages: 947-955
-
[Journal Article]2012
Author(s)
Tsuchiya KJ, Tsutsumi H, Matsumoto K, Takei N, Narumiya M, Honda M, Thanseem I, Anitha A, Suzuki K, Matsuzaki H, Iwata Y, Nakamura K, Mori N, for HBC Study Team
-
Journal Title
PLoS One
Volume: 7
Pages: e52057
-
-
[Journal Article] Archives of General Psychiatry2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, KikuchiM, Takei N, Sugiyama T, Irie T, Mori N
Volume
68
Pages
306-13
-
[Journal Article]2011
Author(s)
Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N
-
Journal Title
-
[Journal Article]2011
Author(s)
SudaS, Iwata K, Shimmura C, Kameno Y, Anitha A, Thanseem I, Nakamura K, Matsuzaki H, Tsuchiya KJ, Sugihara G, Iwata Y, Suzuki K, Koizumi K, Higashida H, Takei N, Mori N
-
Journal Title
Molecular Autism
Volume: 2
Pages: 14
-
[Journal Article]2011
Author(s)
Matsumoto K, Tsuchiya KJ, Itoh H, Kanayama N, Suda S, Matsuzaki H, Iwata Y, Suzuki K, Nakamura K, Mori N, Takei N, HBC Study Team
-
Journal Title
Journal of Affective Disorders
Volume: 133
Pages: 607-10
-
[Journal Article]2011
Author(s)
Mori T, Tsuchiya KJ, Matsumoto K, Suzuki K, Mori N, Takei N, HBC Study Team
-
Journal Title
Journal of Affective Disorders
Volume: 135
Pages: 341-46
-
[Journal Article]2011
Author(s)
Shimmura C, Suda S, Tsuchiya KJ, Hashimoto K, Ohno K, Matsuzaki H, Iwata K, Matsumoto K, Wakuda T, Kameno Y, Suzuki K, Tsujii M, Nakamura K, Takei N, Mori N
-
Journal Title
PLoS One
Volume: 6
Pages: e25340
-
[Journal Article]2011
Author(s)
Iwata K, Matsuzaki H, Miyachi T, Shimmura C, Suda S, Tsuchiya KJ, Matsumoto K,Suzuki K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Sato K, Mori N
-
Journal Title
Molecular Autism
Volume: 2
Pages: 16
-
[Journal Article]2010
Author(s)
Tsuchiya KJ, Matsumoto K, Suda S, Miyachi T, Itoh H, KanayamaN, Hirano K, Ohzeki T, Takei N, HBC Study Team
-
Journal Title
Journal of Developmental Origins of Health and Disease
Volume: 1
Pages: 158-73
-
[Journal Article]
Author(s)
Frasch K, Larsen JI, Cordes J, Jacobsen B, Wallenstein Jensen SO, Lauber C,Nielsen JA, Tsuchiya KJ, Uwakwe R, Munk-Jorgensen P, Kilian R, Becker T
-
Journal Title
International Journal of Social Psychiatry
-
[Presentation] Postpartum depression and prepregnancy BMI: The Hamamatsu Birth Cohort (HBC) Study[conference proceeding]2010
Author(s)
Mori T, Tsuchiya KJ, Matsumoto K, Muraki H, Takahashi S, Takabayashi R, Suzuki Y, Sato R, Narumiya M, Takei N, HBC Study Team
Organizer
Longitudinal and Life Course Studies 1 (suppl 3): 372
Year and Date
20100000
-
-
-
-
