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2012 Fiscal Year Final Research Report

1nvolvement of hyperglycemiaand dietary AGEs inthe prevention of life style-related disease

Research Project

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Project/Area Number 22300264
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKanazawa Medical University (2011-2012)
Hokuriku University (2010)

Principal Investigator

TAKEUCHI Masayoshi  金沢医科大学, 総合医学研究所, 教授 (20154982)

Co-Investigator(Kenkyū-buntansha) TAKINO Jun-ichi  広島国際大学, 薬学部, 助教 (00440529)
Project Period (FY) 2010 – 2012
Keywords生活習慣病 / Toxic AGEs(TAGE) / RAGE / 食後高血糖 / 食事性AGEs / 果糖 / 清涼飲料水 / 加工食品
Research Abstract

Recently, we demonstrated that glyceraldehyde-derived AGEs (Glycer-AGEs), the predominant components of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients. Moreover, a growing body of evidence suggests that the interaction of TAGE with the receptor for AGEs (RAGE) alters intracellular signaling, gene expression, and the release of pro-inflammatory molecules and elicits oxidative stress generation in numerous types of cells, all of which may contribute to the pathological changes observed in diabetic vascular complications, hypertension, dementia, cancer, nonalcoholic steatohepatitis and sterility. It became clear that postprandial hyperglycemia, overeating of fructose or dietary AGEs causes generation of TAGE and over-expression of RAGE in a growing body, and is involving of development and progression of life style-related disease.

  • Research Products

    (35 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (15 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Serum levels of advanced glycation end products(AGEs) are independently correlated with circulating levels of dipeptidyl peptidase-4 (DPP-4) in humans.2013

    • Author(s)
      TaharaN,Yamagishi,TakeuchiM(3/8)et・al.
    • Journal Title

      Clin, Biochem

      Volume: 46 Pages: 300-303

    • DOI

      doi:10.1016/j.clinbiochem.2012.11.023.

    • Peer Reviewed
  • [Journal Article] Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome:The JAPAN-ACS Sub-study.2013

    • Author(s)
      Fukushima Y, Daida H, Takeuchi M(7/13) et al.
    • Journal Title

      Cardiovasc, Diabetol.

      Volume: 12 Pages: 5

    • DOI

      doi:10.1186/1475-2840-12-5.

    • Peer Reviewed
  • [Journal Article] 血管障害バイオマーカーとしてのtoxic AGEs(TAGE)2013

    • Author(s)
      血亙正義
    • Journal Title

      医学のあゆみ

      Volume: 244(8) Pages: 685-690

  • [Journal Article] Positive association between serum level of glyceraldehyde-derived advanced glycation end products (AGEs) and vascular inflammation evaluated by18F-fluorodeoxy- glucose positron emission tomography (FDG-PET).2012

    • Author(s)
      Tahara N, Yamagishi S, Takeuchi M
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 2618-2625

    • DOI

      doi:10.2337/dc12-0087.

    • Peer Reviewed
  • [Journal Article] Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects.2012

    • Author(s)
      UedaS, Yamagishi S, Takeuchi M
    • Journal Title

      Cardiovasc.Ther

      Volume: 30 Pages: 249-254

    • DOI

      doi:10.1111/j.1755-5922.2011.00264.x.

    • Peer Reviewed
  • [Journal Article] Glycer-AGEs-RAGE signaling enhances the angiogenic potential of HCC by upregulating VEGF expression.2012

    • Author(s)
      Takino J, Yamagishi S, and Takeuchi M
    • Journal Title

      World J.Gastroenterol.

      Volume: 18 Pages: 1781-1788

    • DOI

      doi:103748/wjg.vl8.il5.1781

    • Peer Reviewed
  • [Journal Article] Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in non-diabetic subjects.2012

    • Author(s)
      TaharaN, YamagishiS, TakeuchiM
    • Journal Title

      Cardiovasc.Ther.

      Volume: 30 Pages: 42-48

    • DOI

      doi:10.1111/j.1755-5922.2010.00177.x.

    • Peer Reviewed
  • [Journal Article] 生活習慣病の発症・進展におけるToxicAGEs(TAGE)-RAGE系の関与:一新たな治療戦略一2012

    • Author(s)
      血担正義
    • Journal Title

      二金沢医科大学薙話

      Volume: 37 Pages: 141-161

    • Peer Reviewed
  • [Journal Article] Toxic advanced glycation end-products: TAGEの多様な疾患への関与2012

    • Author(s)
      血亙正義
    • Journal Title

      fi本薬理難1誌

      Volume: 139 Pages: 193-197

    • Peer Reviewed
  • [Journal Article] AGEsと肝疾患2012

    • Author(s)
      竹内正義
    • Journal Title

      Anti-aging Medicine

      Volume: 8 Pages: 55-61

  • [Journal Article] Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology.2011

    • Author(s)
      Jinno M, Takeuchi M
    • Journal Title

      Hum.Reprod.

      Volume: 26 Pages: 604-610

    • DOI

      doi:10.1093/humrep/deq388.

    • Peer Reviewed
  • [Journal Article] Involvement of the toxic AGEs (TAGE)- RAGE system in the pathogenesis of diabetic vascular complications:A novel therapeutic strategy.2010

    • Author(s)
      Takeuchi M, Takino J, and Yamagishi S
    • Journal Title

      Curr.DrugTargets

      Volume: 11 Pages: 1468-1482

  • [Journal Article] Cancer malignancy is enhanced by glyceraldehyde-derived advanced glycation end-products.2010

    • Author(s)
      Takino J, Yamagishi S, and Takeuchi M
    • Journal Title

      Z.Oncol.2010

      Volume: 739852

    • DOI

      doi:10.1155/2010/739852.

    • Peer Reviewed
  • [Journal Article] Immunological detection of fructose-derived advanced glycation end-products.2010

    • Author(s)
      Takeuchi M, Iwaki M, Takino J etal.
    • Journal Title

      Lab.Invest.

      Volume: 90 Pages: 1117-1127

    • DOI

      doi:10.1038/1abinvest.2010.62.

    • Peer Reviewed
  • [Journal Article] The formation of intracellular glyceraldehyde-derived advanced glycation end-products and cytotoxicity.2010

    • Author(s)
      Takino J,Kobayashi Y and Takeuchi M
    • Journal Title

      J. Gastroenterol

      Volume: 45 Pages: 646-655

    • DOI

      doi:10.1007/sOO535-009-0193-9.

    • Peer Reviewed
  • [Presentation] 生活習慣病の発症・進展におけるToxicAGEs(TAGE)-RAGE系の関与とその阻止2013

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会第133年会ランチョンセミナー特別講演
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-29
  • [Presentation] 糖化を防いで生活習慣病予防~ToxicAGEs(TAGE)-RAGE系からみた新たな戦略~2013

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会東海支部特別講演
    • Place of Presentation
      名古屋
    • Year and Date
      2013-01-11
  • [Presentation] 糖化を防いで生活習慣病予防!~TAGE-RAGE系からみた新たな治療戦略~2012

    • Author(s)
      竹内正義
    • Organizer
      第5回抗加齢ウイメンズヘルス研究会特別講演
    • Place of Presentation
      東京
    • Year and Date
      2012-11-15
  • [Presentation] 肝細胞癌におけるGlycer-AGEs-RAGEシグナルの影響2012

    • Author(s)
      瀧野純一
    • Organizer
      第51回日本薬学会中国四国支部例会
    • Place of Presentation
      島根
    • Year and Date
      2012-11-10
  • [Presentation] 未病におけるToxicAGEs(TAGE)の関与とその阻止2012

    • Author(s)
      竹内正義
    • Organizer
      第19回日本未病システム学会学術総会シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2012-10-28
  • [Presentation] NASHの発症・進展におけるtoxicAGEs(TAGE)-RAGE系の関与2012

    • Author(s)
      竹内正義
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-08
  • [Presentation] 生活習慣病の発症・進展予防と糖化制御2012

    • Author(s)
      竹内正義
    • Organizer
      第7回日本栄養改善学会北陸支部学術総会特別講演
    • Place of Presentation
      金沢
    • Year and Date
      2012-02-26
  • [Presentation] アンチエイジングにおけるTAGE-RAGE系の関与2011

    • Author(s)
      竹内正義
    • Organizer
      第14回日本補完代替医療学会シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2011-11-05
  • [Presentation] 生活習慣病におけるTAGE-RAGE系の関与とその阻止2011

    • Author(s)
      竹内正義
    • Organizer
      第1回糖化ストレス研究会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
  • [Presentation] NASHの発症・進展におけるTAGE-RAGE系の関与2011

    • Author(s)
      瀧野純一
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
  • [Presentation] 食後高血糖一酸化ストレスー心血管病連関とTAGE-RAGE系のクロストーク2011

    • Author(s)
      竹内正義
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
  • [Presentation] 生活習慣病におけるToxicAGEs(TAGE)-RAGE病因説と食事性AGEsのクロストーク2011

    • Author(s)
      竹内正義
    • Organizer
      第65回日本栄養・食糧学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
  • [Presentation] ToxicAGEs(TAGE)-RAGE病因説から考える未病と栄養2010

    • Author(s)
      竹内正義
    • Organizer
      第17回日本未病システム学会学術総会ワークショップ
    • Place of Presentation
      那覇
    • Year and Date
      2010-11-13
  • [Presentation] 糖尿病血管合併症に関わる食後高血糖及び食事性AGEsとToxicAGEs(TAGE)-RAGE系のクロストーク2010

    • Author(s)
      竹内正義
    • Organizer
      第25回日本糖尿病合併症学会ワークショップ
    • Place of Presentation
      大津
    • Year and Date
      2010-10-22
  • [Presentation] 生活習慣病の発症・進展におけるTAGE病因説と食事性AGEsのクロストーク2010

    • Author(s)
      竹内正義
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-29
  • [Book] AGEsと老化一糖化制御からみたウエルエイジングー2013

    • Author(s)
      血亙正義
    • Total Pages
      229-241
    • Publisher
      メディカルレビュー社
  • [Remarks] (1)金沢医科大学総合医学研究所先端医療研究領域糖化制御研究分野HP

    • URL

      http://mri-ages.kanazawa-med.labos.ac/one/

  • [Remarks] 平成24年度バイオビジネスアワードJAPAN(2013年2月15日)

    • URL

      http://www.bioaward.jp/hyosho_past.php?eid=00004

  • [Remarks] 日本経済新聞(電子版):40代からはじめる「たるみ」「しわ」を防ぐ食事術(2011年11月19日)

    • URL

      http://www.nikkei.com/article/DGXNASFK1700P_X11C11A1000000/

  • [Remarks] 北國健康生きがい支援事業

    • URL

      http://www.kenko-ikigai.com/topics/95-20120508.html

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Published: 2014-08-29  

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