2012 Fiscal Year Final Research Report
Development of comprehensive immunotherapy by defuccosylated antibody
| Project/Area Number |
22300333
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor immunology
|
|---|
| Research Institution | Aichi Medical University (2012)
Nagoya City University (2010-2011) |
|---|
Principal Investigator |
UEDA Ryuzo 愛知医科大学, 医学部, 教授 (20142169)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takashi 名古屋市立大学, 大学院・医学研究科, 准教授 (80405183)
SUZUKI Susumu 愛知医科大学, 医学部, 助教 (70518422)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 低フコシル化抗体 / CCR4 / 制御性T細胞(Treg) / CT 抗原 / 細胞傷害性T細胞(CTL) |
|---|
| Research Abstract |
Therapeutic experimental model in autologous system by antigen specific cytotoxic T lymphocyte (CTL) using human tumor inoculated NOG mice which mimic pathological features of human tumor including micro environment in the tumor. Significant therapeutic effect was demonstrated in Adult T-cell leukemia (ATL) cells inoculated NOG mice treated with infusion of HTLV-1 Tax specific CTL. The therapeutic mouse model in our study will be more important because the analysis of immune dynamism in tumor site is essential for the immunotherapy development.
|
