2012 Fiscal Year Final Research Report
Genetic association study of Behcet's disease in multiple ethnic groups
| Project/Area Number |
22390065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTA Masao 信州大学, 医学部, 准教授 (50115333)
MEGURO Akira 横浜市立大学, 医学研究科, 特任講師 (60508802)
KAWAGOE Tatsukata 横浜市立大学, 医学部, 助教 (20564800)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ゲノム医科学 |
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| Research Abstract |
To identify the susceptibility genes for Behcet’ s disease, we conducted a genome-wide association study in a Japanese population and replication studies in Turkish and Korean populations. We identified two new susceptibility loci, IL23R-IL12RB2 and IL10, for Behcet’ s disease. In addition, we identified further new loci for the disease by re-assessing the GWAS data.
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