2012 Fiscal Year Final Research Report
Application of focal brain cooling for intractable epilepsy
| Project/Area Number |
22390276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
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| Project Period (FY) |
2010 – 2012
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| Keywords | epilepsy / focal brain cooling |
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| Research Abstract |
Safeness of focal brain cooling (FBC) for intractable epilepsy was verified. A rat epilepsy model was treated by the FBC. The optimal temperature to interrupt seizure without deteriorating neuronal function was 15 ℃. The FBC was applied at epilepsy surgery in human. Increased levels of glutamate and lactate reduced at 15 ℃. The FBC effectively inhibit neuronal excitotoxicity and anaerobic metabolism. Newly developed cooling device was successfully applied to cats and monkeys.
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