2013 Fiscal Year Final Research Report
Molecular mechanism of networking system between bone and hematopoietic cells via Wnt signaling pathway
| Project/Area Number |
22390346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAMURA Masato 北海道大学, 歯学研究科(研究院), 教授 (30236757)
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| Co-Investigator(Kenkyū-buntansha) |
NASHIMOTO Masayuki 新潟薬科大学, 応用生物学部, 教授 (30228069)
NEMOTO Eiji 東北大学, 大学院・歯学研究科, 准教授 (40292221)
SATO Mari 北海道大学, 大学院・歯学研究科, 助教 平成25年度 (40546488)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 骨芽細胞 / Wntシグナル / 骨細胞 |
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| Research Abstract |
Canonical Wnt signaling molecule such as Wnt3a down-regulated CXCL12 expression in murine ST-2 cells. The culture supernatant from Wnt3a-ST2 cells also reduced migratory activity of bone marrow-derived cells and hematopoietic cell in a migration assay. Screostin which inhibits canonical Wnt signaling is identified as a signaling molecule from osteocytes to hematopoietic cell. The expression of neuropeptide Y Y1 receptor mRNA was induced by BMP2. These results raise the possibility that NPY acts in osteoblasts and osteocytes via an autocrine mechanism. From this study, functional crosstalk of regulation between bone and the other tissue.
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