2012 Fiscal Year Final Research Report
Study on nerve regeneration in the Maxillofacial domain due to the artificial neural tube (PGA-Collagen tube) using the iPS cell
Project/Area Number |
22390385
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
SHIGENO Keiji 京都大学, 再生医科学研究所, 非常勤講師 (00162587)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
|
Project Period (FY) |
2010 – 2012
|
Keywords | 人工神経管 / PGA-コラーゲンチューブ / イヌiPS細胞 / 神経幹細胞様細胞 / 細胞誘導 / iPS(多分化能)状態の維持 / 神経再生実験 |
Research Abstract |
We were able to get early healing of motor nerves and mixed nerve reproduction by three dimensions culturing dog induced pluripotent stem cells (embryo stem cells) made for the first time in the world in our laboratory to the artificial neural tube which was synthetic macromolecule + collagen complex, and rearranging this with nerve damage region. For neuropathic sharp pain (particularly intractable sharp pain - so-called C.R.P.S) that was taking place for the mandibular nerve damage by this, We were able to develop an effective cure.
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[Journal Article] Fluid overload deteriorate the chylothorax2012
Author(s)
Honda, M., Hori, Y., Shionoya, Y., Yamamoto, K., Kida, N., Kojima, F., Nakamura, T
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Journal Title
Disease of Esophagus. Diseases of the Esophagus
Volume: 25
Pages: 269-272
DOI
Peer Reviewed
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[Journal Article] Transforming Growth Factor β3 for the prevention of vocal fold scarring2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Ishikawa, S., Mizuta, M., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122
Pages: 583-589
DOI
Peer Reviewed
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[Journal Article] Regeneration of Tracheal Epithelium Using a Collagen Vitrigel-Sponge Scaffold Containing Basic Fibroblast Growth Factor2012
Author(s)
Tani, A., Tada, Y., Takezawa, T., Imaizumi, M., Nomoto, Y., Nakamura, T., Omori, K
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Journal Title
Annals of Otology, Rhinology & Laryngology
Volume: 121(4)
Pages: 261-268
Peer Reviewed
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[Journal Article] Regeneration of canine inferior alveolar nerve by polyglycolic acid-collagen tube2012
Author(s)
Shigeno, K., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 569
Peer Reviewed
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[Journal Article] Promotion of bone repairing by use of novel Collagen scaffold in Rabbit skull defect model2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, k., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 591
Peer Reviewed
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[Journal Article] Artificial trachea and In situ tissue engineering:twelve gean-follow up.in canine model2012
Author(s)
Nakamura, T., Fumitsugu, K., Sato, T., Nakada, A., Wakatsuki, M., Sasauchi, K., Kida, N., Kanemaru, S., Omori, K., Kaneko, M., Shigeno, k., Inada, Y., Endo, K
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 608
Peer Reviewed
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[Journal Article] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122(11)
Pages: 2503-2510
DOI
Peer Reviewed
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[Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012
Author(s)
Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
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Journal Title
PLoS One
Volume: 7(11)
Pages: e48873
DOI
Peer Reviewed
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[Journal Article] Implantation of an atelocollagen sponge with autologous bone marrow-derived mesenchymal stromal cells for treatment of vocal fold scarring in a canine model2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Tateya, I.Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 120
Pages: 401-408
Peer Reviewed
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[Journal Article] Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model2011
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Yamamoto, K., Nishizawa, Y., Kojima, F., Shigeno,K
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Journal Title
Journal of Gastroenterology
Volume: 46
Pages: 866-872
DOI
Peer Reviewed
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[Journal Article] Use of adipose-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model2011
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
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Journal Title
Gastrointestinal Endoscopy
Volume: 73
Pages: 777-784
DOI
Peer Reviewed
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[Journal Article] Development of a novel antiadhesive material, alginate flakes, ex vivo and in vivo2011
Author(s)
Hirasaki, Y., Fukunaga, M., Kidokoro, A., Hashimoto, A., Nakamura, T., Tsujimoto, H., Hagiwara, A
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Journal Title
Surg today
Volume: 41
Pages: 970-977
DOI
Peer Reviewed
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[Journal Article] A tissue-engineering approach for stenosis of the trachea and/or cricoid2010
Author(s)
Kanemaru, S., Hirano, S., Umeda, H., Yamashita, M., Suehiro, A., Nakamura, T., Maetani, T., Omori, K., Ito, J
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Journal Title
Acta Otolaryngol Suppl
Volume: 130
Pages: 79-83
DOI
Peer Reviewed
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[Journal Article] Potential of induced pluripotent stem cells for the regeneration of the tracheal wall2010
Author(s)
Imaizumi, M., Nomoto, Y., Sugino, T., Miyake, M., Wada, I., Nakamura, T., Omori, K
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 119
Pages: 697-703
URL
Peer Reviewed
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[Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold gingival fibroblasts and adipose-derived stem cells2010
Author(s)
Kobayashi, K., Suzuki, T., Nomoto, Y., Tada, Y., Miyake, M., Hazama, A., Wada, I., Nakamura, T., Omori, K
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Journal Title
Biomaterials
Volume: 31
Pages: 4855-4863
DOI
Peer Reviewed
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[Journal Article] Generation of canine induced pluripotent stem cells by retroviral transduction and chemical inhibitors2010
Author(s)
Shimada, H., Nakada, A., Hashimoto, Y., Shigeno, K., Shionoya, Y., Nakamura, T
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Journal Title
Molecular Reproduction and Development
Volume: 77
Pages: 2
DOI
Peer Reviewed
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[Journal Article] Treatment of acute vocal fold scar with local injection of basicfibroblast growth factor2010
Author(s)
Suehiro, A., Hirano, S., Kishimoto, Y., Rousseau, B., Nakamura, T., Ito, J
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Journal Title
a canine study. Acta Otolaryngol
Volume: 130
Pages: 844-850
DOI
Peer Reviewed
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[Journal Article] Male sexual dysfunction after rectal cancer surgery2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y
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Journal Title
Colorectal Dis
Volume: 12
Pages: 8-8
Peer Reviewed
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[Journal Article] Observation of the esophagus, pharynx and lingual root bygastrointestinal endoscopy with a percutaneous retrograde approach2010
Author(s)
Honda, M., Hori, Y., Shionoya, Y., Nakada, A., Sato, T., Kobayashi, T., Shimada, H., Kida, N., Nakamura, T
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Journal Title
World J Gastrointest Endosc
Volume: 16
Pages: 288-292
DOI
Peer Reviewed
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[Journal Article] Process of healing of mucosal defects in the esophagus after endoscopic mucosal resection: histological evaluation in a dog model2010
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Nakada, A., Sato, T., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Hashimoto, A., Hashimoto, Y
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Journal Title
Endoscopy
Volume: 42
Pages: 1092-1095
Peer Reviewed
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[Journal Article] Glottal reconstruction with a tissue engineering technique using polypropylene mesh: a canine experiment2010
Author(s)
Yamashita, M., Kanemaru, S., Hirano, S., Umeda, H., Kitani, Y., Omori, K., Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 119(2)
Pages: 110-117
Peer Reviewed
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[Presentation] PROMOTION OF BONE REPAIRING BY USE OF NOVEL COLLAGEN SCAFFOLDS IN RABBIT SKULL DEFECT MODEL2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Year and Date
20120926-29
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[Presentation] REGENERATION OF CANINE INFERIER ALVEOLAR NERVE BY POLGLY-COLIC ACID-COLLAGEN TUBE2012
Author(s)
Shigeno, K., Shionoya, Y., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Year and Date
20120926-29
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[Presentation] The association between anal function and histological neural change after preoperative chemoradiotherapy followed by ISR2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y.
Organizer
15th Congress of the European Society of Surgical Oncology (ESSO)
Place of Presentation
Bordeaux(FRANCE)
Year and Date
20100915-17
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[Presentation] Male sexual dysfunction after rctal cancer surgery2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y
Organizer
5th EUROPIAN SOCIETY OF COLOPRPCTOLOGY (ESCP)
Place of Presentation
Sorrento(Italy)
Year and Date
20100915-17
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[Presentation] Autologous transplantation of adipose-derived stromal cells prevent esophageal stricture after endoscopic mucosal resection in a canine model2010
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
Organizer
第63回日本胸部外科学会
Place of Presentation
大阪
Year and Date
2010-10-26
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[Presentation] Transplantation of adipose-derived stromal cells prevent esophageal stricture after endoscopic mucosal resection in canine model2010
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
Organizer
European Society for Artificial Organs 37thCongress
Place of Presentation
Skopje (Macedonia)
Year and Date
2010-09-10
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