2012 Fiscal Year Final Research Report
The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
| Project/Area Number |
22390396
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuo 新潟大学, 医歯学総合病院, 准教授 (00215344)
KUBOTA Takehiko 新潟大学, 医歯学総合病院, 講師 (50303136)
KOMATSU Yasutaka 新潟大学, 医歯学総合病院, 助教 (40422597)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯周炎 / リウマチ / IL-6 / エピジェネティクス |
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| Research Abstract |
The aim of this study was to elucidate the role of interleukin-6 gene methylation in the pathogenesis of periodontitis and rheumatoid arthritis. The results indicated that the gene contained 19 methylation motifs, and hypomethylated status of a single motif was associated with two diseases. Additionally, methylation level was decreased in the gingival than those in blood, suggesting an increased level of IL-6 gene activity and inflammatory condition.
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