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2012 Fiscal Year Final Research Report

Influenza surveillance in Myanmar: investigations on emergence of drug resistant strains and clinical pictures of H1N1pdm09

Research Project

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Project/Area Number 22406013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionNiigata University

Principal Investigator

SAITO Reiko  新潟大学, 医歯学系, 教授 (30345524)

Co-Investigator(Kenkyū-buntansha) NAITO Makoto  新潟大学, 医歯学系, 教授 (30045786)
HASEGAWA Go  新潟大学, 医歯学系, 准教授 (90251800)
FUJII Masahiro  新潟大学, 医歯学系, 教授 (30183099)
OOIE Masayasu  新潟大学, 医歯学系, 助教 (70108017)
Co-Investigator(Renkei-kenkyūsha) OOHASHI Riuko  新潟大学, 医歯学総合病院, 助教 (20447600)
SAITO Takehiko  独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所, 上席研究員 (00263393)
Project Period (FY) 2010 – 2012
Keywordsインフルエンザ / ミャンマー / 流行時期 / ウイルス遺伝子解析 / ウイルス進化 / 薬剤耐性 / 新型インフルエンザ
Research Abstract

We investigated influenza viruses circulated in the community in Yangon and Nay Pyi Taw in Myanmar during FY 2010-2012. In total we isolated 643 influenza viruses during three years, and 257 were A/H1N1pdm09, 182 A/H3N2, and 204 B. Epidemic season in Myanmar was from May to November during the rainy season. For A/H3N2 and B, new genetic variants appeared a half year earlier than in Japan. Drug resistant surveillance showed that there was no oseltamivir resistant H274Y mutated strains during the years. We identified two drug resistant influenza B that conferred resistance to zanamivir and lanaimivir, and possessed I248G mutation in the NA gene.

  • Research Products

    (13 results)

All 2013 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar2012

    • Author(s)
      Dapat C, Saito R, Kyaw Y, Myint YY, Oo HN, Oo KY, Naito M, Hasegawa G, Dapat IC, Suzuki H
    • Journal Title

      Influenza Other Respi Viruses

      Volume: Nov 5

    • DOI

      doi:10.1111/irv.12030

    • Peer Reviewed
  • [Journal Article] Identification of oseltamivir resistance among pandemic and seasonal influenza A (H1N1) viruses by an His275Tyr genotyping assay using the cycling probe method2011

    • Author(s)
      Suzuki Y, Saito R, Sato I, Zaraket H, Nishikawa M, Tamura T, Dapat C, Caperig-Dapat I, Baranovich T, Suzuki T, Suzuki H
    • Journal Title

      J Clin Microbiol

      Volume: 49(1) Pages: 125-30

    • Peer Reviewed
  • [Journal Article] Genetic makeup of amantadine-resistant and oseltamivir- resistant human influenza A/H1N1 viruses2010

    • Author(s)
      Zaraket H, Saito R, Suzuki Y, Baranovich T, Dapat C, Caperig-Dapat I, Suzuki H
    • Journal Title

      J Clin Microbiol

      Volume: 48(4) Pages: 1085-92

    • Peer Reviewed
  • [Journal Article] New genotypes within respiratory syncytial virus group B genotype BA in Niigata, Japan2010

    • Author(s)
      Dapat IC, Shobugawa Y, Sano Y, Saito R, Sasaki A, Suzuki Y, Kumaki A, Zaraket H, Dapat C, Oguma T, Yamaguchi M, Suzuki H
    • Journal Title

      J Clin Microbiol

      Volume: 48(9) Pages: 3423-7

    • Peer Reviewed
  • [Journal Article] Reduced effectiveness of oseltamivir in children infected with oseltamivir-resistant influenza A (H1N1) viruses with His275Tyr mutation2010

    • Author(s)
      Saito R, Sato I, Suzuki Y, Baranovich T, Matsuda R, Ishitani N, Dapat C, Dapat IC, Zaraket H, Oguma T, Suzuki H
    • Journal Title

      Pediatr Infect Dis J

      Volume: 29(10) Pages: 898-904

    • Peer Reviewed
  • [Journal Article] Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs2010

    • Author(s)
      Dapat C, Suzuki Y, Saito R, Kyaw Y, Myint YY, Lin N, Oo HN, Oo KY, Win N, Naito M, Hasegawa G, Dapat IC, Zaraket H, Baranovich T, Nishikawa M, Saito T, Suzuki H
    • Journal Title

      Emerg Infect Dis

      Volume: 16(3) Pages: 493-6

    • Peer Reviewed
  • [Presentation] Genetic Characterization of Human Influenza A (H3N2) Virus in Myanmar, 2007-20112013

    • Author(s)
      Clyde Dapat、齋藤玲子、齋藤孔良、Isolde Dapat、近藤 大貴、鈴木宏
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      20131113-20121115
  • [Presentation] Epidemiology of Influenza in Myanmar2013

    • Author(s)
      Reiko Saito, Makoto Naito, Yadanar Kyaw, Yi Yi Myint, Khin Yi Oo, Go Hasegawa,Clyde Dapat, Isolde Dapat, Yugo Shobugawa, Kousuke Saito, Hiroshi Suzuki
    • Organizer
      新興・再興感染症に関するアジア・アフリカリサーチフォーラムAARF2013
    • Place of Presentation
      東京都
    • Year and Date
      20130123-20130124
  • [Presentation] 薬剤耐性インフルエンザとその臨床2011

    • Author(s)
      齋藤玲子
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島市
    • Year and Date
      2011-11-07
  • [Presentation] Prevalence of antiviral drug-resistant influenza in Myanmar from 2007 to 20102011

    • Author(s)
      Clyde Dapat, Reiko Saito, Isolde Dapat, Yasushi Suzuki, Makoto Naito, Yadanar Kyaw, Yi Yi Myint, Hiroshi Suzuki
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      札幌市
    • Year and Date
      2011-09-15
  • [Book] 黄金のパゴダミャンマーの光と影2013

    • Author(s)
      内藤眞
    • Total Pages
      231
    • Publisher
      新潟日報事業所
  • [Remarks] 新潟大学大学院医歯学総合研究科実験病理学(第二病理)

    • URL

      http://www.med.niigata-u.ac.jp/pa2/katudouhoukoku.htm

  • [Remarks] ミャンマー訪問記録

URL: 

Published: 2014-08-29  

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