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2012 Fiscal Year Final Research Report

An attempt to analysis of protein expression data as functional data, and cancer individualization diagnosis

Research Project

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Project/Area Number 22500271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionTohoku University (2012)
Japanese Foundation For Cancer Research (2010-2011)

Principal Investigator

MIYATA Satoshi  東北大学, 大学院・医学系研究科, 講師 (60360343)

Co-Investigator(Kenkyū-buntansha) ISOMURA Minoru  島根大学, 医学部, 講師 (40272497)
Co-Investigator(Renkei-kenkyūsha) MATSUURA Masaaki  公益財団法人がん研究会, がんゲノム研究部, 部長 (40173794)
Project Period (FY) 2010 – 2012
Keywordsゲノム統計解析 / 関数データ解析 / 非線型回帰
Research Abstract

To extract functional data from protein expression profile, smoothing for functions with locally different smoothness was applied. We developed theoretical investigation of adaptive free-knot splines (AFKS), and implemented programing for it. We also interpreted that protein expression profile is obtained from probability distributions with indifferentiable points, and we analyzed estimation problem of extremely illegal probability distributions. The optimization of knots of spline functions was attained by optimizing the adaptive model selection criterion (AMSC) with evolutionary algorithms.

  • Research Products

    (16 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (6 results)

  • [Journal Article] Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area2013

    • Author(s)
      Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T
    • Journal Title

      Circ J

      Volume: 77(2) Pages: 490-493

    • URL

      https://www.jstage.jst.go.jp/article/circj/77/2/77_CJ-12-1594/_article

    • Peer Reviewed
  • [Journal Article] The Great East Japan Earthquake Disaster and cardiovascular diseases.2012

    • Author(s)
      Aoki T, Fukumoto Y, Yasuda S, Sakata Y, Ito K, Takahashi J, Miyata S, Tsuji I, Shimokawa H.
    • Journal Title

      Eur Heart J

      Volume: 33(22) Pages: 2796-2803

    • DOI

      DOI:10.1093/eurheartj/ehs288. Epub 2012PMID: 22930461

    • Peer Reviewed
  • [Journal Article] Japanese Society for Cancer of the Colon and Rectum. "Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease?"2012

    • Author(s)
      Akiyoshi T, Watanabe T, Miyata S, Kotake K, Muto T, Sugihara K
    • Journal Title

      Ann Surg

      Volume: 255(6) Pages: 1129-1134

    • DOI

      doi:10.1097/SLA.0b013e3182565d9d. PMID: 22549752

    • Peer Reviewed
  • [Journal Article] Clinical impact ofintraoperative detection of carcinoembryonic antigen mRNA in pleural lavage specimens from nonsmall cell lung cancer patients2012

    • Author(s)
      Satoh Y, Sugai S, Uehara H, Mun M, Sakao Y, Okumura S, Nakagawa K, Ishikawa Y, Miki Y, Miyata S.
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60(8) Pages: 533-540

    • DOI

      DOI:10.1055/s-0031-1298066

    • Peer Reviewed
  • [Journal Article] Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors.2011

    • Author(s)
      Abe M, Miyata S, Nishimura S, Iijima K, Makita M, Akiyama F, Iwase T.
    • Journal Title

      Breast Cancer

      Volume: 18(4) Pages: 268-272

    • DOI

      doi:10.1007/s12282-009-0185-x.

    • Peer Reviewed
  • [Journal Article] Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer2011

    • Author(s)
      Akiyoshi T, Fujimoto Y, Konishi T, Kuroyanagi H, Ueno M, Oya M, Miyata S, Yamaguchi T.
    • Journal Title

      Am J Surg.

      Volume: 201(6) Pages: 726-733

    • DOI

      doi:10.1016/j.amjsurg.2010.03.003

    • Peer Reviewed
  • [Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis2010

    • Author(s)
      Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T
    • Journal Title

      Blood

      Volume: 116(15) Pages: 2768-2775

    • DOI

      doi:10.1182/blood-2009-10-246264

    • Peer Reviewed
  • [Journal Article] Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter.2010

    • Author(s)
      Yamamoto Y, Fujisaki J, Hirasawa T, Ishiyama A, Yoshimoto K, Ueki N, Chino A, Tsuchida T, Hoshino E, Hiki N, Fukunaga T, Sano T, Yamaguchi T, Takahashi H, Miyata S, Yamamoto N, Kato Y, Igarashi M.
    • Journal Title

      Dig Endosc

      Volume: 22(2) Pages: 112-118

    • DOI

      doi:10.1111/j.1443-1661.2010.00945.x.

    • Peer Reviewed
  • [Journal Article] Discriminant model for cytologic distinction of large cell neuroendocrine carcinoma from small cell carcinoma of the lung2010

    • Author(s)
      Hoshi R, Furuta N, Horai T, Ishikawa Y, Miyata S, Satoh Y.
    • Journal Title

      J Thorac Oncol

      Volume: 5(4) Pages: 472-478

    • DOI

      doi:10.1097/JTO.0b013e3181ce3cdd.

    • Peer Reviewed
  • [Journal Article] 適応型モデル選択基準を用いた一般化加法モデルの推定2010

    • Author(s)
      宮田敏
    • Journal Title

      日本統計学会誌

      Volume: Vol.39,Series JNo.2 Pages: 369-391

    • Peer Reviewed
  • [Presentation] New software for imaging mass spectrometry data2012

    • Author(s)
      Masaaki Matsuura, Masaru Ushijima, Akiko Yuba-Kubo, Masatoshi Wakui, Mitsuyo Ohmura, Kurando Hosaka, Takahiro Hayasaka, Noritaka Masaki, Satoshi Miyata, Ikuko Yao, Mitsutoshi Setou, Kiyoshi Ogawa, Shigeki Kajihara
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Chicago, IL. U.S.A.
    • Year and Date
      2012-04-03
  • [Presentation] Results of a nationwide Japanese study on lateral pelvic lymph node metastasis in low rectal cancer: Is it regional or distant disease?2011

    • Author(s)
      T. Akiyoshi, T. Watanabe, S. Miyata, K. Kotake, T. Muto, K. Sugihara (2011)
    • Organizer
      ASCO Annual Meeting: General Poster Session
    • Place of Presentation
      Chicago, Illinois. U.S.A.
    • Year and Date
      20110637
  • [Presentation] イメージング質量分析データに基づいて領域を判別するソフトウェアの開発2011

    • Author(s)
      梶原茂樹、保坂蔵人、宮田敏、早坂孝宏、井上菜穂子、正木紀隆、久保亜希子、涌井昌俊、矢尾育子、小河潔、瀬藤光利、松浦正明
    • Organizer
      第59回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク大阪
    • Year and Date
      2011-09-15
  • [Presentation] Gene Expression classification of human breast cancer2010

    • Author(s)
      Koichi Nagasaki, Minoru Isomura, Masaaki Matsuura, Masaru Ushijima, Satoshi Miyata, Hutoshi Akiyama, TetsuoNoda, Yoshio Miki
    • Organizer
      69th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      20100922-24
  • [Presentation] Development of detection method for novel fusion gene using GeneChip Exon Array2010

    • Author(s)
      Yusaku Wada, Masaaki Matsuura, Minoru Sugawara, Masaru Ushijima, Satoshi Miyata
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association, Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
    • Place of Presentation
      Hilton Waikoloa Village Waikoloa, Hawaii. U.S.A.
    • Year and Date
      20100205-09
  • [Presentation] Prediction of response to cancer chemotherapy by generalized additive model2010

    • Author(s)
      Satoshi Miyata, Masaaki Matsuura
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association, Cancer Genomics, Epigenomics, and theDevelopment of Novel Therapeutic
    • Place of Presentation
      Hilton Waikoloa Village Waikoloa, Hawaii. U.S.A.
    • Year and Date
      20100205-09

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Published: 2014-08-29  

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