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2012 Fiscal Year Final Research Report

Identification and characterization of microRNAs involved in molecular mechanism of emotional memory

Research Project

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Project/Area Number 22500328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionGunma University

Principal Investigator

KOJIMA Nobuhiko  群馬大学, 大学院・医学系研究科, 准教授 (80215251)

Project Period (FY) 2010 – 2012
Keywords恐怖条件づけ / microRNA / 扁桃体 / 遺伝子発現 / マイクロアレイ
Research Abstract

Exploring the molecular mechanism underlying emotional memory is important for understanding not only how the brain works, but also how psychiatric disorder such as PTSD occurs. It has been known that expression of genes involved in the formation and maintenance of long-term fear memory is dynamically changed during the processes of emotional memory. In this study to know the contribution of microRNA in the processes of fear memory formation, genome-wide screening of microRNAs whose expression is altered in the amygdala after fear conditioning using microRNA microarray. As a result,13 microRNAs were identified: 3 were increased and 10 were decreased. Investigation of the role of these microRNAs will allow us a better understanding of the new aspects of communication between the synapse and the nucleus underlying the long-term retention of emotional memory.

  • Research Products

    (9 results)

All 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamineinduced locomotor sensitization2011

    • Author(s)
      Han W, Takamatsu Y, Yamamoto H, Kasai S, Endo S, Shirao T, Kojima N, Ikeda K.
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: e21637

    • Peer Reviewed
  • [Journal Article] Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood2010

    • Author(s)
      Kojima N, Hanamura K, Yamazaki H, Ikeda T,Itohara S, Shirao T.
    • Journal Title

      Neuroscience

      Volume: 165 Pages: 138-150

    • Peer Reviewed
  • [Presentation] Time-dependent effect of X-irradiation on fear conditioning and its underlying cellular mechanism.In the Symposium "Effect on the neural cells and plasticity of the central nervous system.2013

    • Author(s)
      N Koganezawa, A Puspitasari, N Kojima, T Shirao
    • Organizer
      Third Conference of International Society of Radiation Neurobiology
    • Place of Presentation
      Naha, Okinawa, (invited)
    • Year and Date
      2013-01-26
  • [Presentation] Acute effect of X-irradiation on adult mouse brain2013

    • Author(s)
      A Puspitasari, N Koganezawa, N Kojima, T Shirao
    • Organizer
      Third Conference of International Society of Radiation Neurobiology
    • Place of Presentation
      Naha, Okinawa
    • Year and Date
      2013-01-26
  • [Presentation] Isoform-specific distribution and function of drebrin in adult mouse brain2012

    • Author(s)
      Nobuhiko Kojima, Hiroki Yasuda, Kenji Hanamura and Tomoaki Shirao
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] Acute effect of X-irradiation on conditioned fear memory2011

    • Author(s)
      Kojima N, Hanamura K, Shirao T.
    • Organizer
      First annual meeting of International Society of Radiation Neurobiology
    • Place of Presentation
      Maebashi, Japan
    • Year and Date
      2011-01-29
  • [Presentation] Neuron-specific drebrin isoform is necessary for hippocampus-dependent learning in adulthood but not in young age of mice2010

    • Author(s)
      Kojima N, Yasuda H, Hanamura K, Shirao T
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20101113-17
  • [Presentation] Age-dependent impairments of hippocampal synaptic plasticity and hippocampus-dependent learning in drebrin A-specific knockout mice2010

    • Author(s)
      児島伸彦、安田浩樹、花村健次、白尾智明
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸
    • Year and Date
      20100902-04
  • [Presentation] Isoform conversion of drebrin is required for hippocampus-dependent learning and synaptic plasticity in the elderly

    • Author(s)
      児島伸彦、安田浩樹、花村健次、白尾智明
    • Organizer
      第84回日本薬理学会年会、誌上開催

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Published: 2014-08-29  

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