2012 Fiscal Year Final Research Report
Identification and characterization of microRNAs involved in molecular mechanism of emotional memory
| Project/Area Number |
22500328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Gunma University |
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Principal Investigator |
KOJIMA Nobuhiko 群馬大学, 大学院・医学系研究科, 准教授 (80215251)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 恐怖条件づけ / microRNA / 扁桃体 / 遺伝子発現 / マイクロアレイ |
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| Research Abstract |
Exploring the molecular mechanism underlying emotional memory is important for understanding not only how the brain works, but also how psychiatric disorder such as PTSD occurs. It has been known that expression of genes involved in the formation and maintenance of long-term fear memory is dynamically changed during the processes of emotional memory. In this study to know the contribution of microRNA in the processes of fear memory formation, genome-wide screening of microRNAs whose expression is altered in the amygdala after fear conditioning using microRNA microarray. As a result,13 microRNAs were identified: 3 were increased and 10 were decreased. Investigation of the role of these microRNAs will allow us a better understanding of the new aspects of communication between the synapse and the nucleus underlying the long-term retention of emotional memory.
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