2012 Fiscal Year Final Research Report
Effect on hepatic fibrosis of omega-3 fatty acids and their lipid mediators.
| Project/Area Number |
22500768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
KAWAKAMI Takayo (SASAGAWA Takayo) 岡山県立大学, 保健福祉学部, 教授 (10254567)
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| Co-Investigator(Kenkyū-buntansha) |
YUASA Akiko 大阪市立大学, 大学院・生活科学研究科, 准教授 (90295709)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Yasuko 福山大学, 生命工学部, 講師 (90326413)
KAKIBUCHI Naoko 香川短期大学, 生活文化学科, 准教授 (70310886)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 慢性肝疾患 / オメガ3脂肪酸 / 肝線維化 |
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| Research Abstract |
We studied on progression of nonalcoholic Fatty liver disease (NAFLD) focus on anti-inflammatory and anti-fibrotic effect of omega3 fatty acid mediators. We showed that NAS (NAFLD activity score) in NASH model mice fed with EPA oil was significantly lower than control mice. Further, we observed that the addition of resolvins or their precursors to hepatic stellate cell cause reduction of the cellular collagen concentration. These results may derive from inhibition of production or degradation of collagen in HSC. We also investigated the serum CK18 level and its correlation with nutritional parameters in middle-aged Japanese males with NAFLD. We showed that members of the NAFLD group showed higher levels of serum CK18 levels and strongly associated with serum ALT and plasma DGLA. Abnormal fatty acid metabolism may be a factor of aggravation in NAFLD. Further examination including mechanism of omega3 fatty acid mediators on chronic liver disease should be performed.
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