2012 Fiscal Year Final Research Report
Role of H-ficolin. A recognition molecule in innate immunity
| Project/Area Number |
22570144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
ENDO Yuichi 福島県立医科大学, 医学部, 准教授 (20117427)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Teizo 福島県立医科大学, 名誉教授 (20134223)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 免疫学 / 生体分子 / 蛋白質 / レクチン / 補体 |
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| Research Abstract |
To define the role of human H-ficolin in vivo, we generated a model mouse, ficolins A/B double-deficient mouse transiently expressing H-ficolin. In the serum, H-ficolin formed the complexes with serine proteases MASPs and sMAP. H-ficolin recognized a bacterial strain, Streptococcus pneumonia D39, and led to complement activation on this bacterium. The susceptibility of this mouse to bacterial infection is in progress. These results suggest that H-ficolin is involved in first defense against bacterial infection.
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[Journal Article] Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniaeinfection2012
Author(s)
Endo Y, Takahashi M, IwakiD, IshidaY, NakazawaN, KodamaT, MatsuzakaT, KannoK, LiuY, TsuchiyaK, KawamuraI, Ikawa M, WaguriS, WadaI, MatsushitaM, SchwaebleWJ, Fujita T
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Journal Title
J Immunol
Volume: 189
Pages: 5860-5866
DOI
Peer Reviewed
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[Journal Article] The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection2012
Author(s)
Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ
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Journal Title
PLoS Pathogens
Volume: 8
Pages: e1002793
DOI
Peer Reviewed
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research -Secondary Publication2012
Author(s)
Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H, Tsukamoto H, Matsumoto M, Inoue N, Nonaka M, Kinoshita T.
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Journal Title
Allergol Int
Volume: 61(4)
Pages: 559-62
DOI
Peer Reviewed
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