Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku "Burdock Fruit (Seeds of Arctium lappa)"

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: University of Toyama
• Principal Investigator: TEZUKA Yasuhiro 富山大学, 和漢医薬学総合研究所, 准教授 (70236975)
• Co-Investigator(Kenkyū-buntansha): TOYOOKA Naoki 富山大学, 大学院・理工学研究部(工学), 教授 (10217565) ; SURESH Awale 富山大学, 先端ライフサイエンス拠点, 特命助教 (00377243)
• Project Period (FY): 2010 – 2012
• Keywords: 医薬品化学

Research Abstract

From Arctium lappa, Wikstroemia indica, and Trachelospermum asiaticum, we obtained the （-)-arctigenin-relating compounds and measured their preferential cytotoxicity under nutrient-deprived conditions. Based on the preferential cytotoxicity, we have synthesized the （-)-arctigenin derivatives and clarified that the triethoxy derivative shows the important in vitro and in vivo activity identical with those of （-)-arctigenin.

Research Products

• [Journal Article] Anti-austeric Activity of Phenolic Constituents of Seeds of Arctium lappa (2013)
  • Author(s): Tezuka Y., Yamamoto K., Awale S., Li F., Yomoda S., and Kadota S
  • Journal Title: Nat. Prod. Commun Volume: 8(4) Pages: 463-466
  • URL: http://www.naturalproduct.us/
  • Peer Reviewed
• [Journal Article] Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy (2013)
  • Author(s): Kudou N., Taniguchi A., Sugimoto A., Matsuya Y., Kawasaki M., Toyooka N., Miyoshi C., Awale S., Dibwe D.F., Esumi H., Kadota S., and Tezuka Y
  • Journal Title: Eur. J. Med. Chem Volume: 60 Pages: 76-88
  • DOI: DOI:10.1016/j.ejmech.2012.11.031
  • Peer Reviewed
• [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究 (2012)
  • Author(s): 谷口 瑛,工藤直紀,松谷裕二,杉本健士,友廣岳則,畑中保丸,川崎正志,Suresh Awale,李 峰,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
  • Organizer: 第42回複素環化学討論会
  • Place of Presentation: 京都
  • Year and Date: 20121011-13
• [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究 (2011)
  • Author(s): 谷口 瑛,工藤直紀,松谷裕二,杉本健士,川崎正志,Suresh Awale,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
  • Organizer: 平成23年度有機合成化学北陸セミナー
  • Place of Presentation: 福井県坂井市
  • Year and Date: 20111007-08