2012 Fiscal Year Final Research Report
Creation of novel anticancer lead compounds by in silico design of XIAP antagonists
| Project/Area Number |
22590107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TAMURA Seiichi 東京理科大学, 薬学部薬学科, 教授 (10142449)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASAWA Ryoko 東京理科大学, 薬学部・薬学科, 講師 (10398828)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 医薬分子設計 |
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| Research Abstract |
XIAP, which is involved in resistances for anticancer drugs and irradiation, is an attractive target for the development of new anticancer drugs. In this study, we attempted to create novel lead compounds for new anticancer drugs. As a result, we could discover a novel agonistic compound, which possess a good binding form to XIAP.
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