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2012 Fiscal Year Final Research Report

A role of dbpA, DNA binding protein in Hodgkin lymphoma

Research Project

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Project/Area Number 22590338
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionJuntendo University

Principal Investigator

MOMOSE Shuji  順天堂大学, 医学部, 非常勤講師 (70360344)

Co-Investigator(Kenkyū-buntansha) TAMARU Jun-ichi  埼玉医科大学, 医学部, 教授 (30188429)
梶野 一徳  順天堂大学, 医学部, 助教 (80260066)
Project Period (FY) 2010 – 2012
KeywordsCD30 / dbpA / リンパ腫 / 病理学
Research Abstract

dbpA, DNA-binding protein A is belived to be involved in DNA recombination in E.Coli. We found dbpA is highly expressed in CD30 positive lymphocytes, which is restricted to activated lymphocyte in normal tissue. Also dbpA is highlyexpressed in CD30+lymphoma, classical Hodgkin lymphoma and anaplastic lymphoma. As it is well known that constitutive activation of NF・B signaling is a characteristic feature of Hodgkin lymphoma, dbpA seemed to act in a downstream molecule of NF・B signaling pathway.

  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Book (3 results)

  • [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL2012

    • Author(s)
      Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N
    • Journal Title

      Clin Cancer Res

      Volume: 18(8) Pages: 2164-72

    • Peer Reviewed
  • [Journal Article] Microscopic polyangitis complicating double carcinoma of the stomach and duodenum: improvement after the resection of these carcinomas2011

    • Author(s)
      be H, Momose S, Takeuchi T
    • Journal Title

      Rheumatol Int

      Volume: 31(1) Pages: 105-8

    • Peer Reviewed
  • [Journal Article] Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era2010

    • Author(s)
      Hanzawa K, Momose S, Higashi M, Tokuhira M, Watanabe R, Kajino K, Hino O, Itoyama S, Kizaki M, Tamaru J
    • Journal Title

      Leuk Lymphoma

      Volume: 51(11) Pages: 2054-62

    • Peer Reviewed
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010

    • Author(s)
      Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, Izumi H, Abe M, Ohtsuji N, Wang T, Hino O, Fujii H
    • Journal Title

      Hum Pathol

      Volume: 41(9) Pages: 1330-8

    • Peer Reviewed
  • [Book] 血液内科 第64 巻第4 号2012

    • Author(s)
      百瀬修二
    • Publisher
      科学評論社
  • [Book] II.悪性リンパ腫 1.改訂第4 版2010

    • Author(s)
      百瀬修二 田丸淳一
    • Total Pages
      130-134
    • Publisher
      中外医学社
  • [Book] 樋野興夫胸水・腹水の病理 胸腹水の生化学的マーカー -最近の知見-病理と臨牀2010

    • Author(s)
      百瀬修二
    • Total Pages
      1125-1128

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Published: 2014-08-29  

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