2012 Fiscal Year Final Research Report
Development of the method for reducing the adverse effect of arsenic trioxide
| Project/Area Number |
22590504
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
FUJIMURA Akio 自治医科大学, 医学部, 教授 (90156901)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSHIMIZU Takaaki 自治医科大学, 医学部, 准教授 (20392491)
KUMASAKI Msafumi 自治医科大学, 大学院・医学部, 博士課程 (50547966)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床薬理学 |
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| Research Abstract |
We investigated whether α-lipoic acid reduces the cardiotoxicity of arsenic trioxide, an effective medication for acute promyelocytic leukemia, in animal models. Co-treatment with α-lipoic acid attenuated ECG abnormalities acutely caused by a single dose
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