2012 Fiscal Year Final Research Report
A novel treatment for liver injury by modulation oflipid mediator effects
| Project/Area Number |
22590716
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
IKEDA Hitoshi 東京大学, 医学部附属病院, 准教授 (80202422)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMIYA Tomoaki 東京大学, 医学部附属病院, 特任講師 (90227637)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 肝臓学 |
|---|
| Research Abstract |
Portal hypertension is well known as one of critical complications of liver cirrhosis. We have successfully treated portal hypertension in rodent models by inhibiting an effect of sphingosine 1-phosphate, a lipid mediator, with its receptor antagonist. Because our strategy had minimal side effects such as a reduction of arterial pressure, its application in human should be further examined.
|
-
-
-
[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents.2012
Author(s)
Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y.
-
Journal Title
Hepatology
Volume: 56
Pages: 1427-1438
DOI
Peer Reviewed
-
