2012 Fiscal Year Final Research Report
The role of microtubules structure in hepatitis C virus replicationand the possibility of its target molecule for anti-HCV agent
| Project/Area Number |
22590724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
YAMASHITA Atsuya 山梨大学, 大学院・医学工学総合研究部, 助教 (00334871)
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| Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO Nobuyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (20251530)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝臓学 |
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| Research Abstract |
We previously found that the antifungal agent, Griseofulvin, hasa suppressive effect on HCV replication. On the basis of this result, we optimized thestructure of Griseofulvin for searching a new candidate compound of an anti-HCV agentamong Griseofulvin analogues, and analyzed molecular mode of action of Griseofulvinagainst HCV replication. Consequently, we found two Griseofulvin analogues were moreeffective in suppressing HCV replication than Griseofulvin. However, we were unable toclarify molecular mode of action of Griseofulvin against HCV replication.
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