2012 Fiscal Year Final Research Report
Imaging analysis of the role of newly proposed cell surface-associated fibrinolysis mechanism in the regulation of endothelial barrier function.
| Project/Area Number |
22590826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUZUKI Yuko 浜松医科大学, 医学部, 准教授 (20345812)
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| Co-Investigator(Kenkyū-buntansha) |
URANO Tetsumei 浜松医科大学, 医学部, 教授 (50193967)
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管内皮細胞 / 線溶活性 / 可視化解析 / 組織プラスミノゲンアクチベータ |
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| Research Abstract |
Thrombolysis initiation factor , tPA, is secreted from the vascular endothelial cells as an active enzyme. Based on our previous study, in which we visualized the exocytotic dynamics of tPA, we clarified the expression and augmentation mechanisms of thrombolytic activity and the possibility to modulate the cellular function.
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[Journal Article] Life-threatening hemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans2011
Author(s)
Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T, Kanayama N
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Journal Title
J Thromb Haemost
Volume: 9(6)
Pages: 1200-6
DOI
Peer Reviewed
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