2012 Fiscal Year Final Research Report
Gene expression profile induced by viral infection during asthma exacerbation
| Project/Area Number |
22591151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tsukuba University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARINAMI Tadao 筑波大学, 医学医療系, 教授 (10212648)
NOGUCHI Emiko 筑波大学, 医学医療系, 准教授 (40344882)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 喘息 / ウイルス感染 / マイクロアレイ |
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| Research Abstract |
It is well known that asthma exacerbation in pediatric patients is often induced by respiratory viral infection. In the present study, we examined gene expression profile induced by viral infection during asthma exacerbation. Pediatric patients (n=16) who admitted to the hospital due to asthma exacerbation were enrolled in the study. Blood was taken twice from each patient, once during asthma exacerbation and once during a stable period. Total RNA was extracted from peripheral blood mononuclear cells and subjected to microarray analysis. Sixty-five/5 genes were significantly up/down-regulated during asthma exacerbation by microarray analysis. Gene ontology analysis revealed that 21 genes were related to immune reaction, 16 genes for immune reaction against pathogens, 21 genes for defense responses against pathogens, and 7 genes for interferon reactions.
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Research Products
(15 results)
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[Journal Article] Asthma Phenotypes in Japanese Adults-Their Associations with the CCL5 and ADRB2 Genotypes2012
Author(s)
Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Yatagai Y, Yamada H, Konno S, Nishimura M, Noguchi E, Hizawa N
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Journal Title
Peer Reviewed
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[Journal Article] A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype2012
Author(s)
Iijima H, Kaneko Y, Yamada H, Yatagai Y, Masuko H, Sakamoto T, Naito T, Hirota T, Tamari M, Konno S, Nishimura M, Noguchi E, Hizawa N
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Journal Title
Peer Reviewed
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[Journal Article] Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations2011
Author(s)
Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
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Journal Title
PLos Genet
Volume: 7:e1002170
Peer Reviewed
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[Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies2011
Author(s)
Hirota T, Saeki H, Tomita K, Tanaka S, Ebe K, Sakashita M, Yamada T, Fujieda S, Miyatake A, Doi S, Enomoto T, Hizawa N, Sakamoto T, Masuko H, Sasaki T, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Noguchi E, Kamatani N, Nakamura Y, Kubo M, Tamari M
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Journal Title
PLoS One
Volume: 6:e26987
Peer Reviewed
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[Journal Article] Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis2010
Author(s)
Makino Y, Noguchi E, Takahashi N, Matsumoto Y, Kubo S, Yamada T, Imoto Y, Ito Y, Osawa Y, Shibasaki M, Uchida K, Meno K, Suzuki H, Okubo K, Arinami T, Fujieda S
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Journal Title
J Allergy Clin Immunol
Volume: 126
Pages: 1163-9
Peer Reviewed
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[Journal Article] S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population2010
Author(s)
Imoto Y, Enomoto H, Fujieda S, Okamoto M, Sakashita M, Susuki D, Okada M, Hirota T, Tamari M, Ebe K, Arinami T, Noguchi E
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Journal Title
J Allergy Clin Immunol
Volume: 125
Pages: 498-500
Peer Reviewed
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